Document Detail


Inhibition of pacing-induced coronary dilation by aminophylline.
MedLine Citation:
PMID:  1182729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In closed-chest anaesthetized dogs, aminophylline was infused into the left circumflex coronary artery at a rate of 250 mug/min. When the heart rate was lower than 100 beats/min, infusion did not modify the left circumflex coronary blood flow and resistance. When the heart rate was elevated to an average of 153 +/- 6 beats/min by right atrial pacing, infusion inhibited the increase in left circumflex coronary blood flow and decrease in coronary resistance. The pacing-induced increment in coronary blood flow was reduced by an average of 64% and the flow deficit was associated with a lowering of the coronary sinus blood oxygen tension. Since aminophylline is known to inhibit the coronary dilator action of exogenous adenosine, the results support the concept that adenosine resulting from the breakdown of adenine nucleotides is a mediator of the metabolic regulation of coronary blood flow.
Authors:
J Lammerant; I Becsei
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  9     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1976-01-30     Completed Date:  1976-01-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  532-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminophylline / pharmacology*
Animals
Coronary Circulation / drug effects*
Dogs
Female
Heart Rate
Male
Oxygen / blood
Regional Blood Flow / drug effects
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
317-34-0/Aminophylline; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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