Document Detail

Inhibition of the pacemaker current: a bradycardic therapy for off-pump coronary operations.
MedLine Citation:
PMID:  9692455     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The accurate performance of coronary anastomoses on the beating heart requires some form of myocardial immobilization that can be achieved pharmacologically. Different classes of drugs can be used to induce bradycardia, but the most effective in this setting of off-pump operation has not yet been determined. METHODS: Fifty-six isolated buffer-perfused rabbit hearts were divided into seven equal groups. Control hearts were continuously perfused throughout the experimental time course. A second group of hearts underwent 60 minutes of potassium arrest (at 37 degrees C) followed by 1 hour of reperfusion. The following pharmacologic approaches were tested in the remaining five groups: short-acting beta-blockade (esmolol, 6 x 10(-3) mol/L and 3 x 10(-4) mol/L), opening of adenosine triphosphate-dependent potassium channels (nicorandil, 10(-3) mol/L and 10(-5) mol/L), and inhibition of the pacemaker current, which largely accounts for the diastolic depolarization of sinoatrial node cells (S 16257-2, 3 x 10(-6) mol/L). Each drug was infused at a constant rate for 60 minutes, after which hearts were perfused for 1 additional hour with drug-free buffer. Heart rate and isovolumic measurements of function and coronary flow were serially taken during and after drug infusion. RESULTS: The worst recovery of systolic and, moreover, diastolic function was yielded by potassium arrest. Neither esmolol nor nicorandil was able to induce a significant bradycardia. However, nicorandil did not impair function which, conversely, was markedly depressed after esmolol therapy. Significant bradycardia (p < 0.0001 versus corresponding baseline values and versus all other groups) was only achieved with pacemaker current inhibition, which was otherwise associated with an excellent preservation of contractility, diastolic function, and coronary flow. CONCLUSIONS: Inhibition of the pacemaker current seems to be an effective approach for inducing intraoperative bradycardia without compromising left ventricular function or flow.
A Bel; L P Perrault; B Faris; C Mouas; J P Vilaine; P Menasché
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  66     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-14     Completed Date:  1998-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  148-52     Citation Subset:  AIM; IM    
Department of Cardiovascular Surgery and INSERM U-127, Hôpital Lariboisière, Paris, France.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Anti-Arrhythmia Agents / pharmacology
Benzazepines / pharmacology
Bradycardia / chemically induced*
Cardiac Output / drug effects
Cardiac Volume / drug effects
Cardioplegic Solutions / therapeutic use
Cardiopulmonary Bypass
Cardiotonic Agents / pharmacology
Coronary Artery Bypass*
Coronary Circulation / drug effects
Diastole / drug effects
Heart Arrest, Induced
Heart Rate / drug effects
Myocardial Contraction / drug effects
Niacinamide / analogs & derivatives,  pharmacology
Potassium / therapeutic use
Potassium Channels / agonists
Propanolamines / pharmacology
Sinoatrial Node / drug effects*
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Benzazepines; 0/Cardioplegic Solutions; 0/Cardiotonic Agents; 0/Potassium Channels; 0/Propanolamines; 155974-00-8/ivabradine; 65141-46-0/Nicorandil; 7440-09-7/Potassium; 84057-94-3/esmolol; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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