Document Detail

Inhibition of oxidative degradation of hyaluronic acid by uric acid.
MedLine Citation:
PMID:  6488856     Owner:  NLM     Status:  MEDLINE    
It has been postulated that glycosaminoglycans in the trabeculum have an influence on aqueous humor drainage. Ascorbate reduces the viscosity of hyaluronic acid, and also increases outflow facility. Our recent observation of high urate concentrations in some glaucomatous eyes led us to study the influence of urate on oxidative degradation of hyaluronic acid by ascorbate. The viscosity of rooster comb hyaluronic acid was reduced slowly by ascorbate. Cupric sulfate accelerated ascorbate oxidation and also enhanced hyaluronic acid degradation. Urate inhibited ascorbate oxidation and prevented the copper catalyzed oxidative degradation of rooster comb hyaluronic acid. The range of urate concentrations used in this study was within the range of urate concentrations observed in glaucomatous eyes. The partially purified umbilical cord hyaluronic acid had lower viscosity than rooster comb hyaluronic acid, and rapidly degraded in the presence of ascorbate. The ascorbate effect on umbilical cord hyaluronic acid was partially prevented by urate.
K M Liu; D Swann; P Lee; K W Lam
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Current eye research     Volume:  3     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-12-03     Completed Date:  1984-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1049-53     Citation Subset:  IM    
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MeSH Terms
Aqueous Humor / metabolism*
Ascorbic Acid / antagonists & inhibitors,  pharmacology
Copper / pharmacology
Copper Sulfate
Drug Interactions
Glaucoma / metabolism*
Hyaluronic Acid / antagonists & inhibitors,  metabolism*,  pharmacology
Oxidation-Reduction / drug effects
Trabecular Meshwork / metabolism*
Umbilical Cord
Uric Acid / metabolism*,  pharmacology
Grant Support
Reg. No./Substance:
50-81-7/Ascorbic Acid; 69-93-2/Uric Acid; 7440-50-8/Copper; 7758-98-7/Copper Sulfate; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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