Document Detail


Inhibition of ovarian cancer growth and implantation by paclitaxel after laparoscopic surgery in a mouse model.
MedLine Citation:
PMID:  17014818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We used an established experimental model to evaluate the influence of intraperitoneal chemotherapy on the generation of laparoscopy-associated metastases and the effectiveness of chemotherapy. STUDY DESIGN: Twenty-four nude mice underwent laparoscopy with carbon dioxide insufflation and the instillation of a tumor cell suspension with or without paclitaxel into the peritoneal cavity. Mice were allocated to 1 of the following groups (8 mice to each group): (1) controls; (2) paclitaxel given during the operation; (3) paclitaxel given after the operation. Mice were killed 30 days after the procedure, and the peritoneal cavity and port sites were examined for the presence of tumors. RESULTS: Tumor implantation and port-site metastases were reduced more by the intraoperative intraperitoneal administration of paclitaxel during the operation than by administration after the operation. CONCLUSION: Intraoperative intraperitoneal administration of paclitaxel may decrease significantly the occurrence of port-site metastasis and intraperitoneal dissemination in an animal study.
Authors:
Chyi-Long Lee; Nari Kay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-02
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  195     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2006-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1278-81     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Division of Gynecologic Endoscopy, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan. chyilong@ms21.hinet.net
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MeSH Terms
Descriptor/Qualifier:
Abdomen / surgery*
Animals
Antineoplastic Agents, Phytogenic / administration & dosage,  pharmacology*
Cell Line, Tumor
Drug Administration Schedule
Female
Humans
Injections, Intraperitoneal
Intraoperative Period
Laparoscopy / adverse effects*
Mice
Mice, Nude
Neoplasm Seeding
Neoplasm Transplantation
Ovarian Neoplasms / pathology*,  secondary*
Paclitaxel / administration & dosage,  pharmacology*
Postoperative Period
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 33069-62-4/Paclitaxel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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