Document Detail


Inhibition of nociceptive responses of lumbar dorsal horn neurones by remote noxious afferent stimulation in the cat.
MedLine Citation:
PMID:  2841635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In cats anaesthetized with nitrous oxide and sodium pentobarbital, multireceptive lumbar dorsal horn neurones excited by controlled noxious radiant heating of glabrous hind paw skin were recorded by extracellular microelectrodes. These noxious heat responses were inhibited by concomitant noxious stimulation of the ipsilateral forepaw or pinna, or repetitive electrical stimulation of the ipsilateral forelimb deep radial nerve. Similar extents of inhibition were produced by noxious peripheral stimulation and by deep radial nerve stimulation in repetitive trains at intensities sufficient to excite small myelinated fibres or unmyelinated fibres. A greater inhibitory effect was produced by continuous repetitive high-intensity stimulation of the deep radial nerve. With a constant frequency (5 Hz) of continuous deep radial nerve stimulation, graded increases in stimulation intensity revealed the threshold for inhibition in the small myelinated fibre range, and an additional increment of the inhibitory effect when unmyelinated fibres were also activated. When suprathreshold for unmyelinated fibres, the efficacy of continuous deep radial nerve stimulation increased with graded increases in stimulation frequency, with a threshold frequency for inhibition between 0.5 and 1 Hz and maximal effect at 5 Hz. Two nociceptive-specific neurones studied were also inhibited by deep radial nerve stimulation. The results indicate that 'diffuse noxious inhibitory controls' (DNIC) occur in the cat and can be activated by remote electrical or natural noxious stimulation.
Authors:
C R Morton; H J Du; H M Xiao; B Maisch; M Zimmermann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pain     Volume:  34     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-09-22     Completed Date:  1988-09-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  75-83     Citation Subset:  IM    
Affiliation:
Universität Heidelberg, Abteilung Zentralnervensystem, F.R.G.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Electric Stimulation
Female
Hot Temperature
Nerve Fibers / physiology
Nerve Fibers, Myelinated / physiology
Neural Inhibition
Neural Pathways / physiology
Neurons / physiology*
Neurons, Afferent / physiology*
Nociceptors / physiology*
Pain / physiopathology*
Radial Nerve / physiology
Spinal Cord / physiology*
Synaptic Transmission

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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