Document Detail

Inhibition of nitric oxide synthesis potentiates hypoxic vasoconstriction in isolated rat lungs.
MedLine Citation:
PMID:  2340164     Owner:  NLM     Status:  MEDLINE    
We have investigated the influence of endogenous nitric oxide (NO) on the vascular resistance of isolated rat lungs by inhibiting its synthesis with the false substrate N-monomethyl-L-arginine (L-NMMA). When perfused with blood at constant flow the addition of L-NMMA (10(-3) M) did not affect pulmonary arterial pressure in hyperoxia but did increase the response to hypoxia (PO2 25-35 mmHg) by 2.5 +/- 0.2 fold (mean +/- S.E.M.). The effect of L-NMMA was reversed by 3 x 10(-3) M-L-arginine, the true substrate for NO synthesis. Thus NO is an important pulmonary vasodilator but hypoxic vasoconstriction does not result from a reduction of its background release.
B E Robertson; J B Warren; P C Nye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental physiology     Volume:  75     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-25     Completed Date:  1990-06-25     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  255-7     Citation Subset:  IM    
University Laboratory of Physiology, Oxford.
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MeSH Terms
Anoxia / metabolism
Arginine / analogs & derivatives*,  pharmacology
Nitric Oxide* / antagonists & inhibitors
Pulmonary Circulation / drug effects,  physiology*
Pulmonary Wedge Pressure / drug effects,  physiology
Vasoconstriction / drug effects,  physiology*
Grant Support
//Wellcome Trust
Reg. No./Substance:
10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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