Document Detail

Inhibition of nitric oxide synthesis attenuates thermally induced asthma.
MedLine Citation:
PMID:  11457784     Owner:  NLM     Status:  MEDLINE    
To determine whether the inhibition of nitric oxide (NO) synthesis attenuates thermally induced obstruction, we had 10 asthmatic volunteers perform isocapnic hyperventilation with frigid air after inhaling 1 mg of N(G)-monomethyl-L-arginine (L-NMMA) or isotonic saline in a blinded fashion. The challenges were identical in all respects, and there were no differences in baseline lung function [1-s forced expiratory volume (FEV(1)); saline 2.8 +/- 0.3 liters, L-NMMA 2.9 +/- 0.3 liters; P = 0.41] or prechallenge fractional concentration of nitric oxide in the exhaled air (FENO) [saline 23 +/- 6 parts/billion (ppb), L-NMMA 18 +/- 4 ppb; P = 0.51]. Neither treatment had any impact on the FEV(1), pulse, or blood pressure. After L-NMMA, FENO fell significantly (P < 0.0001), the stimulus-response curves shifted to the right, and the minute ventilation required to reduce the FEV(1) 20% rose 53.5% over control (P = 0.02). The results of this study demonstrate that NO generated from the airways of asthmatic individuals may play an important role in the pathogenesis of thermally induced asthma.
C Kotaru; M Skowronski; A Coreno; E R McFadden
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  91     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-17     Completed Date:  2001-09-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-8     Citation Subset:  IM    
Airway Disease Center, Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, Ohio 44106, USA.
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MeSH Terms
Administration, Inhalation
Asthma / physiopathology*
Blood Pressure
Enzyme Inhibitors / administration & dosage,  pharmacology
Forced Expiratory Volume / physiology
Heart Rate
Hemodynamics / physiology*
Hot Temperature*
Middle Aged
Nitric Oxide / analysis
Nitric Oxide Synthase / antagonists & inhibitors
Respiratory Mechanics / physiology
Single-Blind Method
omega-N-Methylarginine / administration & dosage,  pharmacology*
Grant Support
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; EC Oxide Synthase

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