| Inhibition of nitric oxide synthesis attenuates thermally induced asthma. | |
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MedLine Citation:
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PMID: 11457784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether the inhibition of nitric oxide (NO) synthesis attenuates thermally induced obstruction, we had 10 asthmatic volunteers perform isocapnic hyperventilation with frigid air after inhaling 1 mg of N(G)-monomethyl-L-arginine (L-NMMA) or isotonic saline in a blinded fashion. The challenges were identical in all respects, and there were no differences in baseline lung function [1-s forced expiratory volume (FEV(1)); saline 2.8 +/- 0.3 liters, L-NMMA 2.9 +/- 0.3 liters; P = 0.41] or prechallenge fractional concentration of nitric oxide in the exhaled air (FENO) [saline 23 +/- 6 parts/billion (ppb), L-NMMA 18 +/- 4 ppb; P = 0.51]. Neither treatment had any impact on the FEV(1), pulse, or blood pressure. After L-NMMA, FENO fell significantly (P < 0.0001), the stimulus-response curves shifted to the right, and the minute ventilation required to reduce the FEV(1) 20% rose 53.5% over control (P = 0.02). The results of this study demonstrate that NO generated from the airways of asthmatic individuals may play an important role in the pathogenesis of thermally induced asthma. |
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Authors:
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C Kotaru; M Skowronski; A Coreno; E R McFadden |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 91 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-07-17 Completed Date: 2001-09-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 703-8 Citation Subset: IM |
Affiliation:
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Airway Disease Center, Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, Ohio 44106, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Asthma / physiopathology* Blood Pressure Enzyme Inhibitors / administration & dosage, pharmacology Female Forced Expiratory Volume / physiology Heart Rate Hemodynamics / physiology* Hot Temperature* Humans Hyperventilation Male Middle Aged Nitric Oxide / analysis Nitric Oxide Synthase / antagonists & inhibitors Pulse Respiratory Mechanics / physiology Single-Blind Method omega-N-Methylarginine / administration & dosage, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-07288/HL/NHLBI NIH HHS; HL-33791/HL/NHLBI NIH HHS; M01-RR-00080/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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