Document Detail


Inhibition of nitric oxide synthase reduces ultrasonic vocalizations of rat pups.
MedLine Citation:
PMID:  10556664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study investigated the effects of drugs acting on the brain nitric oxide pathway on ultrasonic vocalizations, body temperature and locomotion in 7-8-day-old rat pups. Both a selective neuronal nitric oxide synthase (NOS) inhibitor (7-nitroindazole) and a non-selective NOS inhibitor (nitro-L-arginine-methyl ester, L-NAME) decreased the number of ultrasonic vocalizations in a dose-dependent manner. The non-selective NOS inhibitor, L-NAME, suppressed not only ultrasonic vocalizations but also locomotion. The inactive isomer of the NOS inhibitor, nitro-D-arginine-methyl ester (D-NAME), and the biological precursor of nitric oxide, L-arginine, had no effect on ultrasonic vocalizations or locomotion. These data indicate that drugs suppressing nitric oxide synthesis produced an anxiolytic effect in rat pups. However, only the selective NOS inhibitor, 7-nitroindazole, was 'anxioselective', i.e., reduced ultrasonic vocalizations without causing sedation. Increased synthesis of nitric oxide in the brain had no apparent behavioral effect in this model.
Authors:
J Podhorna; R E Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  382     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-01-04     Completed Date:  2000-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  143-50     Citation Subset:  IM    
Affiliation:
Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Anti-Anxiety Agents / pharmacology
Arginine / pharmacology
Body Temperature / drug effects
Dose-Response Relationship, Drug
Enzyme Inhibitors / pharmacology*
Indazoles / pharmacology
Motor Activity / drug effects
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / metabolism
Nitric Oxide Synthase / antagonists & inhibitors
Rats
Rats, Long-Evans
Stereoisomerism
Ultrasonics
Vocalization, Animal / drug effects*
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Enzyme Inhibitors; 0/Indazoles; 10102-43-9/Nitric Oxide; 2942-42-9/7-nitroindazole; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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