Document Detail

Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury.
MedLine Citation:
PMID:  8595519     Owner:  NLM     Status:  MEDLINE    
The function of nitric oxide (NO) in hemorrhagic shock is controversial. Increased NO synthesis has been temporally correlated with severe shock and has been associated with vascular hyporeactivity to vasoconstrictor agents in isolated vascular rings. Its role in local tissue perfusion, however, is unknown. We studied the role of NO in shock-induced hepatic injury in a rodent model of decompensated hemorrhagic shock by inhibiting its synthesis with Nw-nitro-L-arginine methyl ester (L-NAME). L-NAME infusion (5 micrograms/kg/min) increased the shock-induced hepatic injury and this effect was reversible with L-arginine. L-NAME had only transient effects on systemic mean arterial blood pressure, which quickly returned to pre-L-NAME levels. We conclude that NO synthesis serves a protective function in preventing shock-induced hepatic injury and we postulate that this effect may be due to modulation of the local hepatic circulation.
B G Harbrecht; B Wu; S C Watkins; H P Marshall; A B Peitzman; T R Billiar
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  4     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-04-17     Completed Date:  1996-04-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  332-7     Citation Subset:  IM    
Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA.
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MeSH Terms
Analysis of Variance
Arginine / analogs & derivatives*,  toxicity
Blood Pressure / drug effects
Disease Models, Animal
Enzyme Inhibitors / toxicity*
Infusions, Intravenous
Liver / blood supply,  drug effects*,  enzymology
Liver Circulation / drug effects*
NG-Nitroarginine Methyl Ester
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase / antagonists & inhibitors*
Rats, Sprague-Dawley
Shock, Hemorrhagic / pathology,  physiopathology*,  therapy
Time Factors
Grant Support
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; EC Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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