Document Detail

Inhibition of neutrophil activity in cardiac surgery with cardiopulmonary bypass: a novel strategy with the leukocyte inhibition module.
MedLine Citation:
PMID:  15072250     Owner:  NLM     Status:  MEDLINE    
Recently, we showed that the arterial in-line application of the leukocyte inhibition module (LIM) within the heart-lung machine limits overshooting leukocyte activity and cardiac tissue damage. Moreover, significantly better cardiac function was found in an experimental animal model when LIM was used. In the meantime, the first promising clinical data exist. LIM has to be regarded as an essential tool in extracorporeal circulation, in the future, to improve postoperative clinical outcome and to reduce costs. This review summarizes the biological background of LIM and the current experience obtained in experimental models and clinical studies.
José Bitu Moreno; Stefan Margraf; Alina M Schuller; A Simon; A Moritz; M Scholz
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Perfusion     Volume:  19     ISSN:  0267-6591     ISO Abbreviation:  Perfusion     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-04-09     Completed Date:  2004-10-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8700166     Medline TA:  Perfusion     Country:  England    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Department of Vascular Surgery, Medical Faculty of Marília (FAMEMA), Sao Paulo, Brazil.
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MeSH Terms
Antibodies, Monoclonal / administration & dosage
Antigens, CD95 / immunology
Cardiac Surgical Procedures*
Cardiopulmonary Bypass*
Coated Materials, Biocompatible
Extracorporeal Circulation
Filtration / instrumentation
Leukapheresis / instrumentation*
Neutrophil Activation* / drug effects
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD95; 0/Coated Materials, Biocompatible

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