| Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinib. | |
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MedLine Citation:
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PMID: 22258128 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction:We investigated the use of dietary omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) in the treatment of neuroblastoma both as a sole agent and in combination with sunitinib, a broad-spectrum tyrosine kinase receptor inhibitor.Results:Substitution of all dietary fat with menhaden oil (ω-3 PUFA rich) resulted in a 40-70% inhibition of tumor growth and a statistically significant difference in the levels of several PUFAs (18:2 ω-6, 20:4 ω-6, 22:4 ω-6, 20:5 ω-3) as compared with a control diet. Furthermore, tumors from animals on the ω-3 fatty acid (FA)-enriched diet had an elevated triene/tetraene ratio suggestive of a change in local eicosanoid metabolism in these tissues similar to that seen with essential fatty acid deficiency. The ω-3 FA-enriched diet also decreased tumor-associated inflammatory cells and induced mitochondrial changes suggestive of mitochondrial damage. Combination treatment with sunitinib resulted in further reduction in tumor proliferation and microvessel density.Discussion:These findings suggest a potential role for ω-3 PUFAs in the combination treatment of neuroblastoma.Methods:We used a murine model of orthotopic and subcutaneous human neuroblastoma and diets that differ in the FA content to define the optimal dietary ω-3/omega-6 (ω-6) FA ratio required for the inhibition of these tumors. |
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Authors:
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Carmen M Barnés; Daniela Prox; Emily A Christison-Lagay; Hau D Le; Sarah Short; Flavia Cassiola; Dipak Panigrahy; Deviney Chaponis; Catherine Butterfield; Deepika Nehra; Erica M Fallon; Mark Kieran; Judah Folkman; Mark Puder |
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Publication Detail:
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Type: Journal Article Date: 2011-12-21 |
Journal Detail:
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Title: Pediatric research Volume: 71 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 168-78 Citation Subset: IM |
Affiliation:
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Vascular Biology Program, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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