Document Detail

Inhibition of neointimal proliferation after bare metal stent implantation with low-pressure drug delivery using a paclitaxel-coated balloon in porcine coronary arteries.
MedLine Citation:
PMID:  22237489     Owner:  NLM     Status:  Publisher    
A variety of mechanical and laser-based methods remove or shift atherosclerotic plaques and reopen the artery to its original lumen. Subsequent treatment with drug-coated balloons (DCB) may smooth the vessel wall but does not require high-pressure inflation. We investigated the efficacy of paclitaxel-coated balloons inflated with only 2 atm after bare metal stent implantation in coronary arteries of 24 pigs. Angiography and histomorphometry was performed on day 28. DCB inflated with 2 atm caused similar reduction of late lumen loss (LLL) as high-pressure inflation with 12 atm (0.89 ± 0.58 vs. 0.72 ± 0.39 mm, p = 0.34). Both DCB treatments significantly (p < 0.01) reduced LLL versus uncoated balloons (1.50 ± 0.51 mm). Treatment with low-pressure DCB resulted in less maximal intimal thickness (0.45 ± 0.15 vs. 0.67 ± 0.25 mm) and neointimal area (2.93 ± 0.73 vs. 3.82 ± 1.27 mm(2)) than treatment with uncoated balloons (p < 0.05). In conclusion, low-pressure treatment with DCB was similarly effective as high-pressure treatment justifying clinical trials in vessels which will benefit from inhibition of neointimal proliferation but may not tolerate high inflation pressure.
Bodo Cremers; Bettina Kelsch; Yvonne P Clever; Neil Hattangadi; Dirk Mahnkopf; Ulrich Speck; Matthias Taupitz; Bruno Scheller
Related Documents :
23289749 - Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects.
18256189 - Targeted deletion of dicer in the heart leads to dilated cardiomyopathy and heart failure.
17721979 - Optical coherence tomography as a tool for measuring morphogenetic deformation of the l...
24423149 - Effects of saxagliptin on early microvascular changes in patients with type 2 diabetes.
13932039 - Electrophysiology of an insect heart.
8309319 - The monophasic action potential technique and its application in cardiac electropharmac...
1825259 - Influence of dilated cardiomyopathy, myocarditis and cardiac transplantation on the rel...
15525619 - Anesthetic management of cesarean delivery in a patient with hypoplastic anemia and sev...
3953959 - Effects of intraluminal hydrostatic pressure on l-methionine absorption in the obstruct...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-12
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  -     ISSN:  1861-0692     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Internal Medicine III, University of Saarland, 66421, Homburg/Saar, Germany,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Risk of Erectile Dysfunction and Retrograde Ejaculation Associated with Thulium Laser Vaporesection ...
Next Document:  Tight junctions in neurological diseases.