Document Detail

Inhibition of mutagenicity of a model nitrosation reaction by naturally occurring phenolics, coffee and tea.
MedLine Citation:
PMID:  6750379     Owner:  NLM     Status:  MEDLINE    
Several plant phenolics, one instant coffee, one instant decaffeinated coffee, one roasted coffee, one Japanese tea, one black Indian tea, and one Chinese tea were examined for their inhibitory properties on mutagenicity resulting from the nitrosation of methylurea. Mutagenicity was estimated as the number of his+ revertants per survivor of Salmonella typhimurium TA1535 which was exposed in suspension to the nitrosation mixtures and the modulating agents for 20 min. Tannic acid, gallic acid and chlorogenic acid suppressed the mutagenicity of the model nitrosation system at concentrations similar to or even lower than ascorbic acid. The three tested coffees and three tested teas exerted an inhibitory effect on the mutagenicity of the test system at doses at which they are consumed.
H F Stich; M P Rosin; L Bryson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  95     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  119-28     Citation Subset:  IM    
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MeSH Terms
Chlorogenic Acid / pharmacology
Gallic Acid / pharmacology
Histidine / genetics
Hydrolyzable Tannins / pharmacology
Methylurea Compounds / metabolism,  pharmacology
Mutagenicity Tests
Mutation / drug effects*
Plant Extracts / pharmacology*
Salmonella typhimurium / genetics
Reg. No./Substance:
0/Coffee; 0/Hydrolyzable Tannins; 0/Methylurea Compounds; 0/Mutagens; 0/Plant Extracts; 0/Tea; 149-91-7/Gallic Acid; 327-97-9/Chlorogenic Acid; 598-50-5/methylurea; 71-00-1/Histidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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