Document Detail

Inhibition of mucopolysaccharide sulfation.
MedLine Citation:
PMID:  6453217     Owner:  NLM     Status:  MEDLINE    
A method of measuring the inhibition of sulfation in mucopolysaccharides employed the coupled enzyme system of Wortman. This procedure utilized the phenol and mucopolysaccharide sulfotransferases of beef cornea extract. Compounds tested against this system included amino acids, salicylates, 2-mercaptoethylamine and a derivative, heterocyclic ethanethiosulfuric acids, arylsulfonamidoethanethiosulfates, and several other compounds. In general, the salicylates and thiosulfates were inhibitory, with sodiumm 2-(4-acetamidobenzenesulfonamido)-ethanethiosulfate being the most inhibitory and 2-mercaptoethylguanidine trithiocarbonic acid the second most inhibitory. Salicylamide and allopurinol, which have been employed in kidney stone therapy, were inhibitors. Kidney stones have a mucopolysaccharide sulfate matrix, which is involved in their growth.
W O Foye; Y L Lai-Chen; B R Patel
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  70     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-51     Citation Subset:  IM    
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MeSH Terms
Chemical Phenomena
Cornea / metabolism
Glycosaminoglycans / metabolism*
Salicylates / pharmacology
Sulfates / metabolism
Thiosulfates / pharmacology
Reg. No./Substance:
0/Glycosaminoglycans; 0/Salicylates; 0/Sulfates; 0/Thiosulfates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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