Document Detail

Inhibition of mouse natural killer activity by cholera toxin.
MedLine Citation:
PMID:  7274638     Owner:  NLM     Status:  MEDLINE    
The treatment of mouse spleen cells with cholera toxin (CT) extracted from Vibrio cholerae greatly reduced natural killer (NK) activity. The inhibition of NK activity was rapidly induced by CT treatment and persisted in the absence of CT. Even a very small amount of CT, such as 0.1 ng/ml, was effective in inhibiting NK activity. The inhibitory effect of CT on NK activity was lost upon preabsorption of CT with brain tissues, but not upon preabsorption with liver or kidney tissues.
S Fuyama; F Sendo; S Watabe; K Seiji; S Arai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gan     Volume:  72     ISSN:  0016-450X     ISO Abbreviation:  Gan     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2014-10-03    
Medline Journal Info:
Nlm Unique ID:  0151745     Medline TA:  Gan     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  141-4     Citation Subset:  IM    
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MeSH Terms
Cell Line
Cholera Toxin / metabolism,  pharmacology*
Cytotoxicity, Immunologic / drug effects*
Dose-Response Relationship, Drug
G(M1) Ganglioside / metabolism
Killer Cells, Natural / drug effects*
Neoplasms, Radiation-Induced
Spleen / cytology
Reg. No./Substance:
37758-47-7/G(M1) Ganglioside; 9012-63-9/Cholera Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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