| Inhibition of mouse hepatocyte intercellular communication by phthalate monoesters. | |
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MedLine Citation:
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PMID: 3203332 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of straight and branched chain phthalate monoesters were examined for their effects on hepatocyte intercellular communication in male B6C3F1 mouse hepatocytes. Intercellular communication was determined autoradiographically following the passage and incorporation of [5-3H]uridine nucleotides from pre-labelled hepatocytes into non-labelled hepatocytes. Intercellular communication was evaluated in hepatocytes after 8 h treatment of straight and branched chain phthalate esters at sublethal concentrations. Straight chain phthalate monoesters (mono(ethyl)phthalate, mono(n-butyl) phthalate, mono(n-hexyl)phthalate, mono(n-octyl)phthalate, mono(n-nonyl)phthalate and mono(isononyl)phthalate) had no effect on hepatocyte intercellular communication. Branched chain phthalate monoesters that contained an ethylalkyl moiety (i.e. mono(2-ethylpropyl) phthalate, mono(2-ethylbutyl)phthalate, mono(2-ethylpentyl)-phthalate and mono(2-ethylhexyl)phthalate) inhibited intercellular communication. These results show a structure-activity relationship in the ability of phthalate monoesters to inhibit intercellular communication in mouse hepatocytes. Based upon previous correlations between inhibition of intercellular communication in hepatocytes and hepatocarcinogenicity, these data suggest that branched chain phthalate esters may be liver carcinogens in male B6C3F1 mice. |
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Authors:
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J E Klaunig; R J Ruch; A B DeAngelo; W H Kaylor |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer letters Volume: 43 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-02-09 Completed Date: 1989-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 65-71 Citation Subset: IM |
Affiliation:
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Department of Pathology, Medical College of Ohio, Toledo 43699. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication / drug effects Intercellular Junctions / drug effects* Liver / drug effects* Male Mice Phthalic Acids / pharmacology* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Phthalic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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