| Inhibition of motility in isolated horse small intestine is mediated by κ but not µ opioid receptors. | |
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MedLine Citation:
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PMID: 21883413 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The effects of preferential µ (morphine), selective µ (fentanyl), selective κ (compound U69593) opioid receptor agonists, and nonselective (naloxone) and selective µ (naloxonazine) antagonists on equine small intestinal motility were evaluated in vitro. Samples of circular muscle from equine jejunum were placed in isolated organ baths and drug-induced modifications of both spontaneous and electrically evoked contractile activity were measured. None of the opioid agonists induced a significant change in spontaneous contractions. Fentanyl and U69593 reduced electrically induced contractions, whereas morphine reduced them only slightly. Naloxone competitively antagonised U69593, but both naloxone and naloxonazine were unable to counteract the inhibition of contractions induced by fentanyl. The inhibition of contractions shown by fentanyl is therefore probably not mediated by opioid receptors, but due to an anticholinergic activity of this drug. In summary, these data showed an inhibitory effect exerted by κ receptors on equine small intestinal motility, whereas the role of µ receptors seemed marginal and would need further characterisation. |
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Authors:
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A Menozzi; C Pozzoli; C Zullian; E Poli; P Serventi; S Bertini |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-23 |
Journal Detail:
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Title: Equine veterinary journal Volume: - ISSN: 2042-3306 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-9-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 EVJ Ltd. |
Affiliation:
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Departments of Animal Health and Human Anatomy, Pharmacology and Medico-Forensic Sciences, University of Parma, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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