Document Detail


Inhibition of mixed function oxidases in rat liver by trans- and cis-1,2-dichloroethylene.
MedLine Citation:
PMID:  684758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A single 8-h exposure to trans-1,2-dichloroethylene (t-DCE) or cis-1,2-dichloroethylene (c-DCE) at 200 ppm (hygienic standard in workplaces) resulted in a significant increase in the hexobarbital sleeping time, the zoxazolamine paralysis time, and the metabolic formation of 4-aminoantipyrine from aminopyrine in adult female Wistar rats. Higher DCE concentrations caused a dose-dependent and substantial enhancement of these effects, the effects of c-DCE being stronger than that of t-DCE. In the course of enzyme-kinetic measurements in isolated rat liver microsomes, t-DCE proved to be a competitive inhibitor of the oxidative N-demethylation of aminopyrine and of the O-demethylation of p-nitroanisole. It is concluded from the results that the inhibition of hepatic drug metabolism is caused by a competitive and reversible interaction of the 2 DCE isomers with the mixed-function oxidase system, the interaction possibly operating at the type I binding site.
Authors:
K J Freundt; J Macholz
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  10     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-10-18     Completed Date:  1978-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  131-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dichloroethylenes / pharmacology*
Female
Hexobarbital / pharmacology
Hydrocarbons, Chlorinated / pharmacology*
Kinetics
Liver / enzymology*
Microsomes, Liver / enzymology
Mixed Function Oxygenases / antagonists & inhibitors*
Oxidoreductases / antagonists & inhibitors*
Paralysis / chemically induced
Rats
Sleep / drug effects
Stereoisomerism
Time Factors
Zoxazolamine / pharmacology
Chemical
Reg. No./Substance:
0/Dichloroethylenes; 0/Hydrocarbons, Chlorinated; 56-29-1/Hexobarbital; 61-80-3/Zoxazolamine; EC 1.-/Mixed Function Oxygenases; EC 1.-/Oxidoreductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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