Document Detail


Inhibition of mitochondrial cholesterol side-chain cleavage by structural analogs of cholesterol sulfate.
MedLine Citation:
PMID:  1879379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cholesterol sulfate inhibits cholesterol side-chain cleavage in adrenal mitochondria. In this study, analogs of cholesterol sulfate were evaluated for their ability to inhibit steroidogenesis. Structural requirements for inhibitory activity included a planar A-B ring junction, an intact side chain, and a 3 beta-ester group containing a single negative charge. This structural specificity argues against cholesterol sulfate acting solely as a membrane perturbing agent or a detergent, and also differs in some features from the specificity for binding to cytochrome P-450scc.
Authors:
D G Robertson; D Perry; J D Lambeth
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrine research     Volume:  17     ISSN:  0743-5800     ISO Abbreviation:  Endocr. Res.     Publication Date:  1991  
Date Detail:
Created Date:  1991-10-03     Completed Date:  1991-10-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8408548     Medline TA:  Endocr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  297-306     Citation Subset:  IM    
Affiliation:
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / metabolism,  ultrastructure
Animals
Cholesterol / metabolism*
Cholesterol Esters / chemistry,  pharmacology*
Cholesterol Side-Chain Cleavage Enzyme / metabolism
Male
Mitochondria / metabolism*
Molecular Structure
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
DK01872/DK/NIDDK NIH HHS; DK27373/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 1256-86-6/cholesteryl sulfate; 57-88-5/Cholesterol; EC 1.14.15.6/Cholesterol Side-Chain Cleavage Enzyme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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