Document Detail


Inhibition of marine biofouling by bacterial quorum sensing inhibitors.
MedLine Citation:
PMID:  21882898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seventy eight natural products from chemical libraries containing compounds from marine organisms (sponges, algae, fungi, tunicates and cyanobacteria) and terrestrial plants, were screened for the inhibition of bacterial quorum sensing (QS) using a reporter strain Chromobacterium violaceum CV017. About half of the natural products did not show any QS inhibition. Twenty four percent of the tested compounds inhibited QS of the reporter without causing toxicity. The QS inhibitory activities of the most potent and abundant compounds were further investigated using the LuxR-based reporter E. coli pSB401 and the LasR-based reporter E. coli pSB1075. Midpacamide and tenuazonic acid were toxic to the tested reporters. QS-dependent luminescence of the LasR-based reporter, which is normally induced by N-3-oxo-dodecanoyl-L-homoserine lactone, was reduced by demethoxy encecalin and hymenialdisin at concentrations >6.6 μM and 15 μM, respectively. Hymenialdisin, demethoxy encecalin, microcolins A and B and kojic acid inhibited responses of the LuxR-based reporter induced by N-3-oxo-hexanoyl-L-homoserine lactone at concentrations >0.2 μM, 2.2 μM, 1.5 μM, 15 μM and 36 μM, respectively. The ability to prevent microfouling by one of the compounds screened in this study (kojic acid; final concentrations 330 μM and 1 mM) was tested in a controlled mesocosm experiment. Kojic acid inhibited formation of microbial communities on glass slides, decreasing the densities of bacteria and diatoms in comparison with the control lacking kojic acid. The study suggests that natural products with QS inhibitory properties can be used for controlling biofouling communities.
Authors:
Sergey Dobretsov; Max Teplitski; Mirko Bayer; Sarath Gunasekera; Peter Proksch; Valerie J Paul
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Biofouling     Volume:  27     ISSN:  1029-2454     ISO Abbreviation:  Biofouling     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2012-01-03     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9200331     Medline TA:  Biofouling     Country:  England    
Other Details:
Languages:  eng     Pagination:  893-905     Citation Subset:  IM    
Affiliation:
Department of Marine Science and Fisheries, College of Agricultural and Marine Sciences, Sultan Qaboos University, Sultanate of Oman. sergey@squ.edu.om
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibiotics, Antineoplastic / pharmacology
Azepines / pharmacology
Biofouling / prevention & control*
Biological Agents / pharmacology*
Chromobacterium / drug effects*,  metabolism
Oligopeptides / pharmacology
Pigments, Biological / metabolism
Pyrones / pharmacology
Pyrroles / pharmacology
Pyrrolidines / pharmacology
Quorum Sensing / drug effects*
Tenuazonic Acid / pharmacology
Grant Support
ID/Acronym/Agency:
P41 GM086210/GM/NIGMS NIH HHS; P41M806210//PHS HHS
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Azepines; 0/Biological Agents; 0/Oligopeptides; 0/Pigments, Biological; 0/Pyrones; 0/Pyrroles; 0/Pyrrolidines; 141205-31-4/microcolin A; 141205-32-5/microcolin B; 610-88-8/Tenuazonic Acid; 6K23F1TT52/kojic acid; 95569-43-0/hymenialdisine
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