Document Detail


Inhibition of lysophosphatidic acid-induced neurite retraction and cell rounding by SR 57746A.
MedLine Citation:
PMID:  9473704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rapid neurite retraction and transient rounding of serum-starved NG108-15 and PC12 cells by lysophosphatidic acid (LPA) is retarded and reduced by pre-incubation of the cells with the small non-peptidic molecule, SR 57746A, which exhibits neurotrophic properties. The compound also antagonizes the redistribution of filamentous actin by LPA in both cell types. We hypothesize that the SR 57746A attenuation of LPA-induced effects may account for at least some of the neuroprotective properties of this molecule.
Authors:
M Magazin; P Schiltz; J L Zachayus; E Cavrois; D Caput; P Ferrara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research. Molecular brain research     Volume:  53     ISSN:  0169-328X     ISO Abbreviation:  Brain Res. Mol. Brain Res.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-20     Completed Date:  1998-04-20     Revised Date:  2005-07-21    
Medline Journal Info:
Nlm Unique ID:  8908640     Medline TA:  Brain Res Mol Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Affiliation:
Sanofi Recherche, Voie 1, Labège Innopole, B.P. 137, 31676 Labège, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Glioma
Hybrid Cells
Lysophospholipids / antagonists & inhibitors,  pharmacology*
Naphthalenes / pharmacology*
Neurites / drug effects*,  physiology,  ultrastructure
Neuroblastoma
PC12 Cells
Pyridines / pharmacology*
Rats
Time Factors
Chemical
Reg. No./Substance:
0/Lysophospholipids; 0/Naphthalenes; 0/Pyridines; 135354-02-8/xaliproden

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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