| Inhibition of lymphatic absorption of cholesterol by cholestane-3 beta, 5 alpha, 6 beta-triol. | |
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MedLine Citation:
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PMID: 5356754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of cholestane-3,5alpha,6-triol (CT) on the intestinal absorption of cholesterol and oleic acid, as well as the absorption of labeled CT, was studied in lymph ductcannulated rats. Intragastric administration of 50 mg of CT in an emulsion with cholesterol-7alpha-(3)H and oleic acid-1-(14)C resulted in 50% inhibition of sterol transfer into lymph but only 8% depression of fatty acid absorption over an 8 hr period. The absorption of labeled CT into lymph was only 2-3% compared with 50% absorption of cholesterol when each was fed alone. 10% of the fed CT was recovered in the intestinal mucosa, and of this, one-half was associated with the brush border fraction. In rats fed CT 6 days prior to cholesterol and fatty acid administration, there was no effect on fatty acid absorption, while cholesterol absorption was reduced by almost 30%. When the intestinal mucosa from these animals were investigated by electron microscopy, it appeared that CT feeding resulted in numerous enlarged mitochondria and a marked increase in length of the microvilli. If animals were allowed to recover for 6 days from the CT prefeeding regime, the intestinal mucosa appeared normal, and the absorption of cholesterol approached that in controls. A possible mechanism for CT inhibition of cholesterol absorption was shown to be competition for the enzyme cholesterol esterase which esterifies cholesterol prior to entrance into the lymphatic system. CT itself is poorly esterified and poorly absorbed, but it is effective in inhibiting esterification of cholesterol in vitro. |
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Authors:
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M Ito; W E Connor; E J Blanchette; C R Treadwell; G V Vahouny |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of lipid research Volume: 10 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1969 Nov |
Date Detail:
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Created Date: 1970-01-22 Completed Date: 1970-01-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 694-702 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis Carbon Isotopes Cholestanes / metabolism*, pharmacology Cholesterol / metabolism* Chromatography, Gas Depression, Chemical Esterases / metabolism Esters / biosynthesis Fatty Acids / metabolism Intestinal Absorption / drug effects* Intestinal Mucosa / metabolism Lymph / metabolism* Male Microscopy, Electron Mitochondria / physiology Oleic Acids / metabolism Rats Tritium |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Cholestanes; 0/Esters; 0/Fatty Acids; 0/Oleic Acids; 10028-17-8/Tritium; 57-88-5/Cholesterol; EC 3.1.-/Esterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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