| Inhibition of luteal function by oxytocin antagonist in goats (Capra hircus). | |
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MedLine Citation:
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PMID: 1552489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Early corpus luteum development in nonpregnant and pregnant goats was characterized by a steady increase in peripheral plasma concentrations of progesterone and a high release of prostacyclin (PGI-2) but low release of prostaglandin F-2 alpha (PGF-2 alpha). Jugular administration of oxytocin antagonist (OXA) (0.2 microgram/kg/day) on the day of oestrus and for 3 days thereafter to cyclic and mated goats, significantly (P less than 0.001) inhibited progesterone and prostaglandin secretion and reduced conception rate. Co-administration of PGI-2 (200 micrograms/day) with OXA resulted in a steady increase of progesterone and establishment of pregnancy, but co-administration of PGF-2 alpha (175 micrograms/day) with OXA had no effect. It is suggested that oxytocin is required for early development of the corpus luteum and such effects may be mediated via PGI-2 production. |
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Authors:
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A M Homeida; M M Al-Eknah |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of reproduction and fertility Volume: 94 ISSN: 0022-4251 ISO Abbreviation: J. Reprod. Fertil. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-04-24 Completed Date: 1992-04-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376367 Medline TA: J Reprod Fertil Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 279-85 Citation Subset: IM |
Affiliation:
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College of Veterinary Medicine and Animal Resources, King Faisal University, Saudi Arabia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corpus Luteum / drug effects*, growth & development, physiology Depression, Chemical Dinoprost / blood, pharmacology Epoprostenol / blood, pharmacology Estrus / blood, drug effects* Female Goats / physiology* Oxytocin / antagonists & inhibitors* Pregnancy Pregnancy, Animal / blood, drug effects* Progesterone / blood Vasotocin / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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35121-78-9/Epoprostenol; 50-56-6/Oxytocin; 551-11-1/Dinoprost; 57-83-0/Progesterone; 77327-44-7/vasotocin, 1-(beta-mercapto-beta,beta-diethylpropionic acid)-(OEt-Tyr)(2)-Orn(8)-; 9034-50-8/Vasotocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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