| Inhibition of lung permeability changes after burn and smoke inhalation by an anti-interleukin-8 antibody in sheep. | |
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MedLine Citation:
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PMID: 19408077 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the effects of a monoclonal antibody against interleukin-8 (K2.2) on the microvascular fluid flux after combined injury by burn and smoke inhalation. METHODS: Fourteen sheep were prepared surgically by placing a lung lymph catheter and a flank lymph catheter to examine the microvascular fluid flux. After a recovery period, they were subjected to a combined injury of 40% third-degree burns on the flank and smoke inhalation. RESULTS: This combined injury induced a rapid increase in burned tissue lymph flow (b-Q(L)) and a delayed-onset increase in lung lymph flow (l-Q(L)). The initial increase in b-Q(L) was associated with an elevation of the lymph-to-plasma oncotic pressure ratio, which led to a predominant increase in the burned tissue permeability index (b-PI). Pretreatment with K2.2 had no effect on the permeability change seen in the burned tissue; however, the lung permeability changes were attenuated by pretreatment with K2.2. CONCLUSION: These findings indicate that the pathogenesis of the increase in microvascular fluid flux seen after the combined injury differs in burned tissue and the lung. |
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Authors:
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Hiroyuki Sakurai; Kazutaka Soejima; Frank C Schmalstieg; Motohiro Nozaki; Daniel L Traber |
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Publication Detail:
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Type: Journal Article Date: 2009-04-30 |
Journal Detail:
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Title: Surgery today Volume: 39 ISSN: 1436-2813 ISO Abbreviation: Surg. Today Publication Date: 2009 |
Date Detail:
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Created Date: 2009-05-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204360 Medline TA: Surg Today Country: Japan |
Other Details:
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Languages: eng Pagination: 399-406 Citation Subset: IM |
Affiliation:
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Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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