Document Detail

Inhibition of lung permeability changes after burn and smoke inhalation by an anti-interleukin-8 antibody in sheep.
MedLine Citation:
PMID:  19408077     Owner:  NLM     Status:  In-Process    
PURPOSE: To evaluate the effects of a monoclonal antibody against interleukin-8 (K2.2) on the microvascular fluid flux after combined injury by burn and smoke inhalation. METHODS: Fourteen sheep were prepared surgically by placing a lung lymph catheter and a flank lymph catheter to examine the microvascular fluid flux. After a recovery period, they were subjected to a combined injury of 40% third-degree burns on the flank and smoke inhalation. RESULTS: This combined injury induced a rapid increase in burned tissue lymph flow (b-Q(L)) and a delayed-onset increase in lung lymph flow (l-Q(L)). The initial increase in b-Q(L) was associated with an elevation of the lymph-to-plasma oncotic pressure ratio, which led to a predominant increase in the burned tissue permeability index (b-PI). Pretreatment with K2.2 had no effect on the permeability change seen in the burned tissue; however, the lung permeability changes were attenuated by pretreatment with K2.2. CONCLUSION: These findings indicate that the pathogenesis of the increase in microvascular fluid flux seen after the combined injury differs in burned tissue and the lung.
Hiroyuki Sakurai; Kazutaka Soejima; Frank C Schmalstieg; Motohiro Nozaki; Daniel L Traber
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Publication Detail:
Type:  Journal Article     Date:  2009-04-30
Journal Detail:
Title:  Surgery today     Volume:  39     ISSN:  1436-2813     ISO Abbreviation:  Surg. Today     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  399-406     Citation Subset:  IM    
Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.
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