| Inhibition of the lower oesophageal sphincter by fat--a mechanism for fatty food intolerance. | |
MedLine Citation:
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PMID: 4706907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of fat and protein meals on the lower oesophageal sphincter pressure was tested in normal subjects using an infused open-tipped manometric system. After ingestion of a minced beef meal, the mean peak pressure at the lower oesophageal sphincter increased 5.8 +/- 1.5 mm Hg (+/- 1 SE). By contrast, ingestion of a corn oil meal resulted in a mean peak decrease of 7.8 +/- 1.9 mm Hg. Following the combined minced beef/corn oil meal, mean peak pressure decreased 3.0 +/- 2.1 mm Hg. Pentagastrin (3 mug/kg, subcutaneously) resulted in a mean peak increase of 20.6 +/- 7.0 mm Hg when given to the subjects in the fasting state, and produced an increase of only 8.4 +/- 1.7 mm Hg when given following the fat meal. Finally, after a mean peak decrease in pressure at the lower oesophageal sphincter of 6.8 +/- 1.0 mm Hg 15 minutes after the corn oil meal, gastric alkalinization with 30 ml of antacid resulted in a subsequent increase in sphincter pressure of 5.2 +/- 1.6 mm Hg. These data indicate: (1) Fat attenuates the effect of endogenous gastrin as well as exogenous pentagastrin stimulation of the lower oesophageal sphincter. (2) Fat-induced incompetency of the lower oesophageal sphincter can be effectively combated by gastric alkalinization in the form of antacids. |
Authors:
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O T Nebel; D O Castell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gut Volume: 14 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 1973 Apr |
Date Detail:
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Created Date: 1973-07-24 Completed Date: 1973-07-24 Revised Date: 2010-09-13 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 270-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antacids Dietary Fats* Dietary Proteins Esophagogastric Junction / physiology* Fasting Fats* Food Hypersensitivity / etiology* Gastrins Humans Male Meat Oils Pentagastrin Pressure Zea mays |
| Chemical | |
Reg. No./Substance:
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0/Antacids; 0/Dietary Fats; 0/Dietary Proteins; 0/Fats; 0/Gastrins; 0/Oils; 5534-95-2/Pentagastrin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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