Document Detail

Inhibition of the lower oesophageal sphincter by fat--a mechanism for fatty food intolerance.
MedLine Citation:
PMID:  4706907     Owner:  NLM     Status:  MEDLINE    
The effect of fat and protein meals on the lower oesophageal sphincter pressure was tested in normal subjects using an infused open-tipped manometric system. After ingestion of a minced beef meal, the mean peak pressure at the lower oesophageal sphincter increased 5.8 +/- 1.5 mm Hg (+/- 1 SE). By contrast, ingestion of a corn oil meal resulted in a mean peak decrease of 7.8 +/- 1.9 mm Hg. Following the combined minced beef/corn oil meal, mean peak pressure decreased 3.0 +/- 2.1 mm Hg. Pentagastrin (3 mug/kg, subcutaneously) resulted in a mean peak increase of 20.6 +/- 7.0 mm Hg when given to the subjects in the fasting state, and produced an increase of only 8.4 +/- 1.7 mm Hg when given following the fat meal. Finally, after a mean peak decrease in pressure at the lower oesophageal sphincter of 6.8 +/- 1.0 mm Hg 15 minutes after the corn oil meal, gastric alkalinization with 30 ml of antacid resulted in a subsequent increase in sphincter pressure of 5.2 +/- 1.6 mm Hg. These data indicate: (1) Fat attenuates the effect of endogenous gastrin as well as exogenous pentagastrin stimulation of the lower oesophageal sphincter. (2) Fat-induced incompetency of the lower oesophageal sphincter can be effectively combated by gastric alkalinization in the form of antacids.
O T Nebel; D O Castell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  14     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1973 Apr 
Date Detail:
Created Date:  1973-07-24     Completed Date:  1973-07-24     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  270-4     Citation Subset:  AIM; IM    
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MeSH Terms
Dietary Fats*
Dietary Proteins
Esophagogastric Junction / physiology*
Food Hypersensitivity / etiology*
Zea mays
Reg. No./Substance:
0/Antacids; 0/Dietary Fats; 0/Dietary Proteins; 0/Fats; 0/Gastrins; 0/Oils; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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