Document Detail

Inhibition of liver protein synthesis during laparoscopic surgery.
MedLine Citation:
PMID:  10516117     Owner:  NLM     Status:  MEDLINE    
Previous studies have indicated that laparoscopic surgery is associated with a decline in liver protein synthesis. In this study, the fractional synthesis rate (FSR) of total liver protein and albumin was measured in patients undergoing elective laparoscopic cholecystectomy at different times after commencing the procedure (n = 8 + 8). Liver biopsy specimens were taken after 15 min of surgery in an "early" group and after 49 min of surgery in a "late" group. The liver FSR was higher in the early group (24.1 +/- 4.7%/day) compared with the late group (19.0 +/- 2.8%/day, P < 0.02). The fractional and absolute synthesis rates of albumin were similar in the two groups, 6.4 +/- 1.5 vs. 6.5 +/- 1.0%/day and 97 +/- 19 vs. 96 +/- 18 mg. kg(-1). day(-1) for the early and late groups, respectively. It is concluded that laparoscopic surgery was accompanied by a decrease in total liver protein synthesis rate, which developed rapidly during surgery. In contrast, no change in the synthesis rate of albumin was apparent during the course of surgery.
H Barle; B Nyberg; S Ramel; P Essén; M A McNurlan; J Wernerman; P J Garlick
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  277     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-22     Completed Date:  1999-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E591-6     Citation Subset:  IM    
Department of Anesthesiology, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden.
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MeSH Terms
Cholecystectomy / adverse effects
Intraoperative Period
Laparoscopy / adverse effects*
Liver / metabolism*,  pathology
Middle Aged
Phenylalanine / metabolism
Protein Biosynthesis*
Proteins / antagonists & inhibitors*
Serum Albumin / biosynthesis
Time Factors
Reg. No./Substance:
0/Proteins; 0/Serum Albumin; 63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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