| Inhibition of lipid synthesis by beta beta'-tetramethyl-substituted, C14-C22, alpha, omega-dicarboxylic acids in cultured rat hepatocytes. | |
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MedLine Citation:
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PMID: 4008497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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beta beta'-Methyl-substituted, C14-C18, alpha, omega-dicarboxylic acids (MEDICA 14-18) were found to inhibit fatty acids and cholesterol synthesis in cultured rat hepatocytes. Maximum inhibition was observed with MEDICA 16, amounting to a 50% decrease in 3H2O and acetate incorporation into fatty acids and cholesterol in the presence of 0.08 mM of the drug added to the culture medium. Inhibition of lipogenesis was not accompanied by inhibition of palmitate or glycerol esterification into neutral lipids and phospholipids. The respective capacities of MEDICA homologues of varying acyl chain length as inhibitors of fatty acid and cholesterol synthesis in cultured rat hepatocytes and in vivo (Bar-Tana, J., Rose-Kahn, G., and Srebnik, M. (1985) J. Biol. Chem. 260, 8404-8410) correlated well with their respective inhibitory effect on liver ATP-citrate lyase. Thus, MEDICA 16 inhibited liver ATP-citrate lyase competitively to citrate with a Ki of 16 microM as compared to a Km of 0.8 mM for the citrate substrate. |
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Authors:
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G Rose-Kahn; J Bar-Tana |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 260 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-08-16 Completed Date: 1985-08-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 8411-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetyl Coenzyme A
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metabolism Animals Biological Transport Cells, Cultured Cholesterol / biosynthesis Citrates / metabolism Citric Acid Dicarboxylic Acids / pharmacology* Dose-Response Relationship, Drug Glucose / metabolism Lipids / biosynthesis* Liver / drug effects, metabolism* Malonyl Coenzyme A / metabolism Methylation Mitochondria, Liver / metabolism Palmitic Acid Palmitic Acids / metabolism Rats Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Citrates; 0/Dicarboxylic Acids; 0/Lipids; 0/Palmitic Acids; 50-99-7/Glucose; 524-14-1/Malonyl Coenzyme A; 57-10-3/Palmitic Acid; 57-88-5/Cholesterol; 72-89-9/Acetyl Coenzyme A; 77-92-9/Citric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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