| Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments. | |
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MedLine Citation:
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PMID: 20530791 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dendritic cells (DCs) play an important role in viral infections both as initiators of immunity and as viral targets. Interaction between DCs and the innate-like CD1d-restricted natural killer T (NKT) cells results in the mutual activation of both cells and the subsequent initiation of cellular immune responses. Here, we show that HIV-1 inhibits the surface expression of CD1d in productively infected DCs and identify this as a novel activity of the HIV-1 vpu gene product. Interestingly, the viral protein U (Vpu) does not enhance constitutive CD1d endocytosis or induce rapid CD1d degradation. Instead, the Vpu protein interacts with CD1d and suppresses its recycling from endosomal compartments to the cell surface by retaining CD1d in early endosomes. This interference with the CD1d antigen presentation pathway strongly inhibits the ability of infected DCs to activate CD1d-restricted NKT cells. Given that the interaction with CD1d-expressing DCs is central to the ability of NKT cells to regulate immunity, these data suggest that interference with the CD1d antigen presentation pathway represents an HIV-1 strategy to evade innate cellular immune responses and imply a role for the innate-like CD1d-restricted NKT cells in the host defense against HIV-1. |
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Authors:
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Markus Moll; Sofia K Andersson; Anna Smed-Sörensen; Johan K Sandberg |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-08 |
Journal Detail:
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Title: Blood Volume: 116 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2010-10-29 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 1876-84 Citation Subset: AIM; IM |
Affiliation:
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Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. markus.moll@ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigen Presentation
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immunology* Antigens, CD1 / metabolism Antigens, CD1d / genetics, immunology*, metabolism Blotting, Western Cell Line Cell Membrane / immunology, metabolism Cells, Cultured Dendritic Cells / immunology*, metabolism, virology Endocytosis / immunology Endosomes / immunology*, metabolism Green Fluorescent Proteins / genetics, metabolism HIV-1 / genetics, immunology, metabolism Human Immunodeficiency Virus Proteins / genetics, immunology*, metabolism Humans Lipids / immunology Lymphocyte Activation / immunology Microscopy, Fluorescence Natural Killer T-Cells / immunology, metabolism Protein Binding Viral Regulatory and Accessory Proteins / genetics, immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AI52731/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD1; 0/Antigens, CD1d; 0/Human Immunodeficiency Virus Proteins; 0/Lipids; 0/Viral Regulatory and Accessory Proteins; 0/vpu protein, Human immunodeficiency virus 1; 147336-22-9/Green Fluorescent Proteins |
| Comments/Corrections | |
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