| Inhibition of iron absorption prolongs the life span of Drosophila. | |
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MedLine Citation:
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PMID: 8326745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The life span of Drosophila melanogaster (Oregon R) males was found to be proportional to the logarithm of the iron content of the diet. Life span was also shown to be proportional to the rate of iron accumulation for Drosophila, mice and man. The total body iron content was found to correlate with the total calcium content of adult Drosophila. Iron content during the developmental stages, however, remained relatively constant and did not change with changes in the calcium concentrations. Dietary tea (Camellia sinensis) extracts were found to inhibit the ageing-related accumulation of iron and to prolong the life span of Drosophila by as much as 21.4%. It is concluded that iron accumulation is a significant factor contributing to senescence. |
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Authors:
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H R Massie; V R Aiello; T R Williams |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 67 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-08-11 Completed Date: 1993-08-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 227-37 Citation Subset: IM |
Affiliation:
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Masonic Medical Research Laboratory, Utica, New York 13501. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Aging Animals Calcium / metabolism Diet Drosophila melanogaster / metabolism* Iron / administration & dosage, metabolism*, pharmacokinetics Longevity Male Tea |
| Chemical | |
Reg. No./Substance:
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0/Tea; 7439-89-6/Iron; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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