Document Detail

Inhibition of intraduodenal trypsin does not stimulate exocrine pancreatic secretion in man.
MedLine Citation:
PMID:  6192029     Owner:  NLM     Status:  MEDLINE    
Inhibition of intraduodenal trypsin stimulates pancreatic secretion in rats and swine. This finding is controversial in healthy humans. The present study was designed to find whether a 'negative-feedback' mechanism exists in man. A 7-lumen tube equipped with two balloons was passed into the duodenum in 18 healthy volunteers. During a constant intravenous infusion of secretin (0.1 CU/kg/h) the duodenum was perfused with 0.9% NaCl solution (20 ml/10 min). Polyethylene glycol (10 g/l) served as nonabsorbable marker. Aprotinin (0.5 X 10(6) KIU/10 min or 1 X 10(6) KIU/10 min) was perfused intraduodenally during periods of constant pancreatic enzyme secretion for 30 min. During perfusion of the trypsin inhibitor aprotinin an almost complete inhibition of trypsin could be observed. However, at the same time or following the perfusion of aprotinin a significant augmentation of amylase, lipase or volume secretion did not occur. Thus, in the present study a negative-feedback control of pancreatic exocrine secretion by the intraduodenal trypsin concentration in man could not be demonstrated.
J Dlugosz; U R Fölsch; W Creutzfeldt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestion     Volume:  26     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1983  
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  197-204     Citation Subset:  IM    
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MeSH Terms
Aprotinin / pharmacology
Bicarbonates / secretion
Bilirubin / secretion
Duodenum / physiology*
Middle Aged
Pancreas / enzymology,  secretion*
Polyethylene Glycols / metabolism
Secretin / secretion
Trypsin / physiology*
Reg. No./Substance:
0/Bicarbonates; 0/Polyethylene Glycols; 1393-25-5/Secretin; 635-65-4/Bilirubin; 9087-70-1/Aprotinin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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