| Inhibition of intimal hyperplasia by direct thrombin inhibitors in an animal vein bypass model. | |
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MedLine Citation:
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PMID: 15253248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many functions of the coagulation system have nonthrombotic effects. The indirect thrombin inhibitor heparin has been previously shown to be effective in limiting intimal hyperplasia (IH). We sought to study the effect of thrombin on IH by using two direct thrombin inhibitors (DTIs), argatroban and lepirudin. Sprague-Dawley rats underwent interposition vein grafting to the carotid artery. Vein grafts were treated with either saline (n = 6) or one of the two DTIs (n = 6 for both). At 30 days, the rats were sacrificed and vessels were perfusion fixed. Sections of the proximal carotid artery, graft, and both anastomoses were stained with both hematoxlyin/eosin and von Gieson's elastin stain. Sections were examined and compared for luminal area and intima-to-media (IM) ratio. The vessels treated with DTIs had less (p < 0.05) IH (IM ratio for proximal anastomosis: control 1.036 +/- 0.857, lepirudin 0.373 +/- 0.21, argatroban 0.182 +/- 0.118) and better lumen preservation than the control vessels (lumen area of proximal anastomosis: control 1.69 +/- 0.9, lepirudin 2.45 +/- 0.74, argatroban 2.81 +/- 0.78). There were no thromboses in the DTI-treated vessels. Dilatation of the graft segment was noted in the argatroban group. Thus, DTIs are effective at reducing IH in a small-animal model, suggesting that inhibition of thrombin has a protective role in IH. In addition, a difference of action between DTIs is suggested by the dilatation seen only in the argatroban-treated graft sections. |
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Authors:
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Leila Mureebe; Susan E Turnquist; Donald Silver |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of vascular surgery Volume: 18 ISSN: 0890-5096 ISO Abbreviation: Ann Vasc Surg Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-07-15 Completed Date: 2004-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703941 Medline TA: Ann Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 147-50 Citation Subset: IM |
Affiliation:
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Division of Vascular Surgery, University of Columbia Health Care, University of Missouri-Columbia, 65212, USA. mureebel@health.missouri.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical Animals Carotid Artery, Common / drug effects, surgery Disease Models, Animal Fibrinolytic Agents / pharmacology Hirudins / analogs & derivatives, pharmacology Hyperplasia / drug therapy, surgery Male Models, Cardiovascular Rats Rats, Sprague-Dawley Recombinant Proteins / pharmacology Thrombin / antagonists & inhibitors* Thrombosis / etiology Tunica Intima / drug effects*, pathology*, surgery Veins / drug effects*, pathology*, surgery |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/Hirudins; 0/Recombinant Proteins; 0/lepirudin; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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