Document Detail


Inhibition of interleukin-10 during pregnancy results in neonatal growth retardation.
MedLine Citation:
PMID:  9127644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: Interleukin 10 is considered to be important in the survival of the fetus in murine pregnancies that are known to be at risk for fetal wastage. The function of IL-10 in a normal pregnancy is not known. METHODS: In this report, we attempted to neutralize Interleukin 10 by administering anti IL-10 monoclonal antibodies (mAb) to pregnant mice that have a low background risk for fetal resorptions. The first group of mice was sacrificed on gestation day 18 to study the fetal effects of anti IL-10 administration. The second group of mice was allowed to deliver to study the effects on the neonatal outcome. RESULTS: Administration of anti IL-10 mAb did not affect the duration of gestation or the fetal outcome. Neonates exposed to anti IL-10 mAb in utero showed signs of transient growth deficiency starting at 4 weeks of age that spontaneously corrected by 6 weeks of age. CONCLUSIONS: Administration of anti IL-10 mAb does not alter the duration of gestation or the fetal outcome in normal murine pregnancies; however, it appears to be associated with transient neonatal growth problems.
Authors:
A G Rijhsinghani; K Thompson; L Tygrette; S K Bhatia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  37     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  232-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City 52242-1080, USA. asha-rijhsinghani@uiowa.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Antibodies, Monoclonal / pharmacology
Birth Weight / drug effects
Cell Differentiation / immunology
Female
Fetal Growth Retardation / etiology*,  immunology*
Interleukin-10 / antagonists & inhibitors*,  immunology*
Male
Mice
Mice, Inbred BALB C
Pregnancy
Pregnancy Outcome
T-Lymphocytes / cytology,  immunology
Thymus Gland / immunology
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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