| Inhibition of interleukin-10 during pregnancy results in neonatal growth retardation. | |
| | |
MedLine Citation:
|
PMID: 9127644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PROBLEM: Interleukin 10 is considered to be important in the survival of the fetus in murine pregnancies that are known to be at risk for fetal wastage. The function of IL-10 in a normal pregnancy is not known. METHODS: In this report, we attempted to neutralize Interleukin 10 by administering anti IL-10 monoclonal antibodies (mAb) to pregnant mice that have a low background risk for fetal resorptions. The first group of mice was sacrificed on gestation day 18 to study the fetal effects of anti IL-10 administration. The second group of mice was allowed to deliver to study the effects on the neonatal outcome. RESULTS: Administration of anti IL-10 mAb did not affect the duration of gestation or the fetal outcome. Neonates exposed to anti IL-10 mAb in utero showed signs of transient growth deficiency starting at 4 weeks of age that spontaneously corrected by 6 weeks of age. CONCLUSIONS: Administration of anti IL-10 mAb does not alter the duration of gestation or the fetal outcome in normal murine pregnancies; however, it appears to be associated with transient neonatal growth problems. |
| | |
Authors:
|
A G Rijhsinghani; K Thompson; L Tygrette; S K Bhatia |
Related Documents
:
|
9192764 - Frequency of immune thrombocytopenia in newborns: a prospective study. immune thrombocy... 1841834 - Copper deficiency and persistence of the ductus arteriosus. 3295284 - Sonographic biophysical profile in the postdate pregnancy. 9056414 - Incomplete differentiation of fetal keratinocytes in the skin equivalent leads to the d... 16123074 - A polymorphism in the mthfd1 gene increases a mother's risk of having an unexplained se... 1362144 - Acute respiratory failure in pregnancy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 37 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 1997 Mar |
Date Detail:
|
Created Date: 1997-06-24 Completed Date: 1997-06-24 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 232-5 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City 52242-1080, USA. asha-rijhsinghani@uiowa.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn Antibodies, Monoclonal / pharmacology Birth Weight / drug effects Cell Differentiation / immunology Female Fetal Growth Retardation / etiology*, immunology* Interleukin-10 / antagonists & inhibitors*, immunology* Male Mice Mice, Inbred BALB C Pregnancy Pregnancy Outcome T-Lymphocytes / cytology, immunology Thymus Gland / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Elevated amniotic fluid interleukin-6 levels during the early second trimester are associated with g...
Next Document: Midtrimester amniotic fluid tumor necrosis factor-alpha does not predict small-for-gestational-age i...