| Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein. | |
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MedLine Citation:
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PMID: 22532687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The V protein of Sendai virus (SeV) suppresses innate immunity, resulting in enhancement of viral growth in mouse lungs and viral pathogenicity. The innate immunity restricted by the V protein is induced through activation of interferon regulatory factor 3 (IRF3). The V protein has been shown to interact with melanoma differentiation-associated gene 5 (MDA5) and to inhibit beta interferon production. In the present study, we infected MDA5-knockout mice with V-deficient SeV and found that MDA5 was largely unrelated to the innate immunity that the V protein suppresses in vivo. We therefore investigated the target of the SeV V protein. We previously reported interaction of the V protein with IRF3. Here we extended the observation and showed that the V protein appeared to inhibit translocation of IRF3 into the nucleus. We also found that the V protein inhibited IRF3 activation when induced by a constitutive active form of IRF3. The V proteins of measles virus and Newcastle disease virus inhibited IRF3 transcriptional activation, as did the V protein of SeV, while the V proteins of mumps virus and Nipah virus did not, and inhibition by these proteins correlated with interaction of each V protein with IRF3. These results indicate that IRF3 is important as an alternative target of paramyxovirus V proteins. |
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Authors:
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Takashi Irie; Katsuhiro Kiyotani; Tomoki Igarashi; Asuka Yoshida; Takemasa Sakaguchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-04-24 |
Journal Detail:
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Title: Journal of virology Volume: 86 ISSN: 1098-5514 ISO Abbreviation: J. Virol. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-08 Completed Date: 2012-08-15 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
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Languages: eng Pagination: 7136-45 Citation Subset: IM |
Affiliation:
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Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals DEAD-box RNA Helicases / deficiency, immunology Immune Evasion* Interferon Regulatory Factor-3 / antagonists & inhibitors*, immunology Mice Mice, Inbred C57BL Mice, Knockout Phosphoproteins / immunology, metabolism Sendai virus / immunology, pathogenicity* Viral Proteins / genetics, immunology, metabolism* Viral Structural Proteins / immunology, metabolism Virulence Factors / deficiency, immunology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/36 kDa V protein, Newcastle disease virus; 0/Interferon Regulatory Factor-3; 0/Irf3 protein, mouse; 0/Phosphoproteins; 0/V protein, Nipah virus; 0/V protein, Paramyxovirus; 0/V protein, Sendai virus; 0/V protein, measles virus; 0/Viral Proteins; 0/Viral Structural Proteins; 0/Virulence Factors; EC 3.6.1.-/DEAD-box RNA Helicases; EC 3.6.1.-/Ifih1 protein, mouse |
| Comments/Corrections | |
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