| Inhibition of in vitro biosynthesis of N-acetylneuraminic acid by N-acyl- and N-alkyl-2-amino-2-deoxyhexoses. | |
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MedLine Citation:
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PMID: 7307017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The biosynthesis of N-acetylneuraminic acid is markedly inhibited by 2-deoxy-2-propionamido-D-glucose (GlcNProp) and to a much lesser extent by 2-deoxy-2-propionamido-D-mannose (ManNProp), but not by 2-deoxy-2-propionamido-D-galactose and N-methylated derivatives of 2-amino-2-deoxy-D-glucose. 2-Deoxy-2-trimethylamino-D-glucose is a weak inhibitor of 2-acetamido-2-deoxy-D-mannose metabolism. When incubated in a cell-free system from rat liver, GlcNProp gives the 6-phosphate, which is converted into N-propionylneuraminic acid. Evidence is presented which shows that it is the metabolites GlcNProp-6-P and ManNProp-6-P which are the competitive inhibitors, and not GlcNProp itself. |
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Authors:
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H J Grünholz; E Harms; M Opetz; W Reutter; M Cerný |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Carbohydrate research Volume: 96 ISSN: 0008-6215 ISO Abbreviation: Carbohydr. Res. Publication Date: 1981 Oct |
Date Detail:
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Created Date: 1982-02-12 Completed Date: 1982-02-12 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0043535 Medline TA: Carbohydr Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 259-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Hexosamines / chemical synthesis, pharmacology* Kinetics Liver / metabolism* Rats Rats, Inbred Strains Sialic Acids / biosynthesis* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Hexosamines; 0/Sialic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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