| Inhibition of in vitro amino acylation and translation by adenosine antibodies. | |
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MedLine Citation:
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PMID: 3178816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adenosine antibodies markedly inhibited in vitro amino acylation of tRNA in a dose-dependent manner. The inhibition was specific as it was reversed by the homologous hapten. Addition of excess tRNA reversed the inhibition indicating that binding of antibodies to tRNA is responsible for inhibition. Adenosine antibodies also inhibited in vitro translation of endogenous mRNAs in rabbit reticulocyte lysate in a dose-dependent manner. The homologous hapten reversed the inhibition showing thereby the immunospecificity of inhibition. |
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Authors:
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Y N Vaishnav; A Antony |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 155 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-11-21 Completed Date: 1988-11-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1381-6 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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immunology* Amino Acyl-tRNA Synthetases / metabolism Animals Antibodies* Dose-Response Relationship, Drug RNA, Transfer, Amino Acyl / immunology* Rats Transcription, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/RNA, Transfer, Amino Acyl; 58-61-7/Adenosine; EC 6.1.1.-/Amino Acyl-tRNA Synthetases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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