Document Detail


Inhibition of human polymorphonuclear leukocyte cell responses by ibuprofen.
MedLine Citation:
PMID:  6502489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The stimulation of cell swelling, cell aggregation, polymorphonuclear leukocyte locomotion, and lysosomal enzyme release in response to chemoattractant were all inhibited by ibuprofen, a nonsteroidal anti-inflammatory agent. The dosages needed to induce 50% inhibition (ID50) were 5.9, 7.6, 60, and 95 micrograms/mL, respectively. Aside from the differences in ID50, there was also a difference in the degree of maximum inhibition (Imax) of the complement C5a-stimulated responses observed, so that at achievable serum drug concentrations of 20-50 micrograms/mL, inhibition of 67-78% for cell swelling, 69-82% for cell aggregation, 20-35% for migration response, and 17-38% for lysosomal enzyme release were demonstrated. Also observed were a minor stimulatory effect on nitroblue tetrazolium reduction and an inhibitory effect on the ability to kill Staphylococcus aureus, but only at very high concentrations (approximately 2 mg/mL).
Authors:
E G Maderazo; S P Breaux; C L Woronick
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  73     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-01-09     Completed Date:  1985-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1403-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Bactericidal Activity
Cell Aggregation / drug effects
Cell Movement / drug effects
Chemotactic Factors / pharmacology
Complement C5 / pharmacology
Complement C5a
Female
Humans
Ibuprofen / pharmacology*
Lysosomes / enzymology
Male
Neutrophils / cytology,  drug effects*
Nitroblue Tetrazolium / metabolism
Staphylococcus aureus / physiology
Chemical
Reg. No./Substance:
0/Chemotactic Factors; 0/Complement C5; 15687-27-1/Ibuprofen; 298-83-9/Nitroblue Tetrazolium; 80295-54-1/Complement C5a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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