Document Detail

Inhibition of human neutrophil phagocytosis and intracellular killing of yeast cells by fluoride.
MedLine Citation:
PMID:  3478039     Owner:  NLM     Status:  MEDLINE    
These processes depend upon the catabolism of glucose, which can be inhibited by fluoride (F-). We studied them with a radiolabelling technique using [3H]-uridine, which is incorporated into viable yeast cells, but hardly at all into neutrophils and dead or phagocytosed yeast cells. Lysis of neutrophils and treatment of the lysate with [3H]-uridine allowed estimation of intracellular killing of yeast cells. F- inhibited neutrophil phagocytosis and intracellular killing in a dose-related manner. Intracellular killing was significantly more sensitive to environmental F- than was phagocytosis. This effect on phagocytosis was not because of inhibition of opsonization of yeast, nor was it related to an effect on medium Ca2+.
W L Gabler; N Hunter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of oral biology     Volume:  32     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-16     Completed Date:  1987-11-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  363-6     Citation Subset:  D; IM    
Department of Biochemistry, Oregon Health Sciences University, School of Dentistry, Portland 97201.
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MeSH Terms
Candida / drug effects*
Cells, Cultured
Dose-Response Relationship, Drug
Fluorides / pharmacology*
Neutrophils / drug effects*
Phagocytosis / drug effects*
Reg. No./Substance:

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