| Inhibition of human glutathione S-transferases by bile acids. | |
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MedLine Citation:
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PMID: 3420615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glutathione S-transferase (GST) isoenzymes isolated from various human tissues are differentially inhibited by bile acids. Trihydroxy bile acid (lithocholate) was found to be more inhibitory to all the human GST isoenzymes tested in this study, as compared to the monohydroxy (cholate) and dihydroxy (chenodeoxycholate) bile acids. Among the three major classes of GST, mu class isoenzymes are generally inhibited to a greater extent than the alpha and pi class isoenzymes. The results of this study also indicate that differential inhibition of GST by various bile acids may be used to distinguish closely related GST isoenzymes within the mu class of GST isoenzyme. Likewise, the pi class or the anionic isoenzymes of human kidney, placenta, and erythrocytes can be distinguished using bile acid inhibition studies. These studies also provide further support for tissue-specific expression of GST isoenzymes in humans. |
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Authors:
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S V Singh; T Leal; Y C Awasthi |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Toxicology and applied pharmacology Volume: 95 ISSN: 0041-008X ISO Abbreviation: Toxicol. Appl. Pharmacol. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-10-27 Completed Date: 1988-10-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0416575 Medline TA: Toxicol Appl Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 248-54 Citation Subset: IM |
Affiliation:
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Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bile Acids and Salts
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pharmacology* Chenodeoxycholic Acid / pharmacology Cholic Acid Cholic Acids / pharmacology Erythrocytes / drug effects, enzymology Glutathione Transferase / antagonists & inhibitors* Humans Isoenzymes / antagonists & inhibitors* Kidney / drug effects, enzymology Lithocholic Acid / pharmacology Liver / drug effects, enzymology Placenta / drug effects, enzymology |
| Grant Support | |
ID/Acronym/Agency:
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CA 27967/CA/NCI NIH HHS; EY 04396/EY/NEI NIH HHS; GM 32304/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Cholic Acids; 0/Isoenzymes; 434-13-9/Lithocholic Acid; 474-25-9/Chenodeoxycholic Acid; 81-25-4/Cholic Acid; EC 2.5.1.18/Glutathione Transferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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