Document Detail

Inhibition of human glutathione S-transferases by bile acids.
MedLine Citation:
PMID:  3420615     Owner:  NLM     Status:  MEDLINE    
Glutathione S-transferase (GST) isoenzymes isolated from various human tissues are differentially inhibited by bile acids. Trihydroxy bile acid (lithocholate) was found to be more inhibitory to all the human GST isoenzymes tested in this study, as compared to the monohydroxy (cholate) and dihydroxy (chenodeoxycholate) bile acids. Among the three major classes of GST, mu class isoenzymes are generally inhibited to a greater extent than the alpha and pi class isoenzymes. The results of this study also indicate that differential inhibition of GST by various bile acids may be used to distinguish closely related GST isoenzymes within the mu class of GST isoenzyme. Likewise, the pi class or the anionic isoenzymes of human kidney, placenta, and erythrocytes can be distinguished using bile acid inhibition studies. These studies also provide further support for tissue-specific expression of GST isoenzymes in humans.
S V Singh; T Leal; Y C Awasthi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  95     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-27     Completed Date:  1988-10-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  248-54     Citation Subset:  IM    
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550.
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MeSH Terms
Bile Acids and Salts / pharmacology*
Chenodeoxycholic Acid / pharmacology
Cholic Acid
Cholic Acids / pharmacology
Erythrocytes / drug effects,  enzymology
Glutathione Transferase / antagonists & inhibitors*
Isoenzymes / antagonists & inhibitors*
Kidney / drug effects,  enzymology
Lithocholic Acid / pharmacology
Liver / drug effects,  enzymology
Placenta / drug effects,  enzymology
Grant Support
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholic Acids; 0/Isoenzymes; 434-13-9/Lithocholic Acid; 474-25-9/Chenodeoxycholic Acid; 81-25-4/Cholic Acid; EC Transferase

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