Document Detail

Inhibition of highly metastatic FBJ-LL cell migration by ganglioside GD1a highly expressed in poorly metastatic FBJ-S1 cells.
MedLine Citation:
PMID:  9070274     Owner:  NLM     Status:  MEDLINE    
For clarification of the functions of gangliosides on tumor metastasis, examination was made of the ganglioside patterns of poorly metastatic FBJ-S1 and highly metastatic FBJ-LL cells. FBJ-S1 cells expressed GM3 and GD1a, whereas FBJ-LL cells expressed GM3 and slightly expressed GD1a. The capacity for FBJ-LL cells to migrate was ten times that of FBJ-S1 cells, but decreased by a half by pretreatment with GD1a. GD1b or GT1b had the same effect as GD1a, and synthetic sialyl compounds to a lesser extent, suggesting that gangliosides contain more than two sialyl residues to inhibit the migration of FBJ-LL cells.
S Hyuga; S Yamagata; T Tai; T Yamagata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  231     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-17     Completed Date:  1997-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  340-3     Citation Subset:  IM    
Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama, Japan.
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MeSH Terms
Chromatography, Thin Layer
Gangliosides / genetics,  physiology*
Mice, Inbred BALB C
Neoplasm Metastasis / genetics
Tumor Cells, Cultured
Reg. No./Substance:
0/Gangliosides; 12707-58-3/ganglioside, GD1a

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