| Inhibition of herpes simplex virus multiplication by activated macrophages: a role for arginase? | |
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MedLine Citation:
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PMID: 6286497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Proteose-peptone-activated mouse macrophages can prevent productive infection by herpes simplex virus in neighboring cells in vitro whether or not those cells belong to the same animal species. The effect does not require contact between the macrophages and the infected cells, may be prevented by adding extra arginine to the medium, and may be reversed when extra arginine is added 24 h after the macrophages. Arginase activity was found both intracellularly and released from the macrophages. The extracellular enzyme is quite stable; 64% activity was found after 48 h of incubation at 37 degrees C in tissue culture medium. No evidence was found that the inefficiency of virus replication in macrophages was due to self-starvation by arginase. As might be predicted macrophages can, by the same mechanism, limit productive infection by vaccinia virus. |
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Authors:
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P Wildy; P G Gell; J Rhodes; A Newton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Infection and immunity Volume: 37 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1982 Jul |
Date Detail:
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Created Date: 1982-10-29 Completed Date: 1982-10-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 40-5 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginase / physiology* Arginine / pharmacology Cell Line Cricetinae Macrophage Activation* Macrophages / enzymology* Mice Mice, Inbred BALB C Simplexvirus / growth & development* |
| Chemical | |
Reg. No./Substance:
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74-79-3/Arginine; EC 3.5.3.1/Arginase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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