Document Detail

Inhibition of hepatitis B virus gene expression by small interfering RNAs targeting cccDNA and X antigen.
MedLine Citation:
PMID:  22404609     Owner:  NLM     Status:  In-Data-Review    
To test the possible inhibition of hepatitis B virus (HBV) replication and expression by small interfering RNAs (siRNAs) targeting simultaneously covalenthy closed circular DNA (dnacccDNA) and X antigen, corresponding recombinant plasmids were transfected into HepG2.2.15 cells and the levels of cccDNA, HBXAg, HBcAg, and HBeAg were assayed at various times post transfection. As expected, the single siRNAs showed marked inhibitory effects but their combination was even more efficient. These results provide a new insight into the development of a potential anti-HBV strategy of enhancing the efficacy of individual antivirals and overcoming the high mutation rate of HBV. Keywords: hepatitis B virus; small interfering RNA; cccDNA; X antigen.
Q Xie; S Zhang; W Wang; Y M Li; T DU; X L Su; Y Q Wei; H X Deng
Related Documents :
22465339 - Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with ...
22658079 - Rescue of recombinant peste des petits ruminants virus: creation of a gfp-expressing vi...
22734679 - Rnai in the regulation of mammalian viral infections.
22328919 - The role of hydrogeography and climate in the landscape epidemiology of west nile virus...
22476529 - Henipaviruses in their natural animal hosts.
22563489 - A novel pathogenic mechanism of highly pathogenic avian influenza h5n1 viruses involves...
12745669 - Development of type 1 diabetes in wild bank voles associated with islet autoantibodies ...
6251439 - Localization of herpesvirus of turkeys in blood cells.
9176409 - Coxsackievirus b3-induced myocarditis. characterization of stable attenuated variants t...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta virologica     Volume:  56     ISSN:  0001-723X     ISO Abbreviation:  Acta Virol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370401     Medline TA:  Acta Virol     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Apoptotic and necrotic changes in cultured murine neurons infected with equid herpesvirus 1.
Next Document:  VP90 of white spot syndrome virus interacts with VP26 and VP28.