Document Detail


Inhibition of hepatitis B virus gene expression by small interfering RNAs targeting cccDNA and X antigen.
MedLine Citation:
PMID:  22404609     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
To test the possible inhibition of hepatitis B virus (HBV) replication and expression by small interfering RNAs (siRNAs) targeting simultaneously covalenthy closed circular DNA (dnacccDNA) and X antigen, corresponding recombinant plasmids were transfected into HepG2.2.15 cells and the levels of cccDNA, HBXAg, HBcAg, and HBeAg were assayed at various times post transfection. As expected, the single siRNAs showed marked inhibitory effects but their combination was even more efficient. These results provide a new insight into the development of a potential anti-HBV strategy of enhancing the efficacy of individual antivirals and overcoming the high mutation rate of HBV. Keywords: hepatitis B virus; small interfering RNA; cccDNA; X antigen.
Authors:
Q Xie; S Zhang; W Wang; Y M Li; T DU; X L Su; Y Q Wei; H X Deng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta virologica     Volume:  56     ISSN:  0001-723X     ISO Abbreviation:  Acta Virol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370401     Medline TA:  Acta Virol     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  IM    
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