| Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid. | |
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MedLine Citation:
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PMID: 502765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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2-Tetradecylglycidic acid (TDGA), a hypoglycemic agent, has been found to be a very effective inhibitor of de novo fatty acid synthesis by isolated hepatocytes. A comparison was made between the effectiveness of TDGA and 5-(tetradecyloxy)-2-furoic acid (TOFA), a hypolipidemic agent, on the metabolic processes of isolated hepatocytes. These compounds are structurally related and both inhibit fatty acid synthesis; however, they have opposite effects from each other on the oxidation and esterification of fatty acids. TDGA inhibits whereas TOFA stimulates fatty acid oxidation. TDGA stimulates whereas TOFA inhibits fatty acid esterification. |
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Authors:
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S A McCune; T Nomura; R A Harris |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lipids Volume: 14 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1979 Oct |
Date Detail:
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Created Date: 1980-01-28 Completed Date: 1980-01-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 880-2 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Drug Epoxy Compounds / pharmacology* Ethers, Cyclic / pharmacology* Fatty Acids / biosynthesis*, pharmacology* Female Hypoglycemic Agents / pharmacology* Kinetics Liver / drug effects, metabolism* Rats Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Epoxy Compounds; 0/Ethers, Cyclic; 0/Fatty Acids; 0/Hypoglycemic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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