Document Detail

Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells.
MedLine Citation:
PMID:  20332434     Owner:  NLM     Status:  MEDLINE    
Previously we found that a fruit-derived polyphenol fraction caused an inhibition of proliferation and an induction of differentiation markers in Caco-2 human colon cancer cells. In the present work, we sought to determine if individual polyphenols would exert similar actions. Proliferation was inhibited by several polyphenolic molecules including gallic acid, ellagic acid, quercetin and resveratrol. In Caco-2 cells, growth inhibition was accompanied by increased specific activities of two differentiation markers, alkaline phosphatase and dipeptidyl peptidase, but not of aminopeptidase. Increased enzyme activities were not seen in HT29 and SW1116 colon cancer cells. In Caco-2 cells there were additive effects of butyrate or valproate and polyphenolic molecules. Histone acetylation was not greatly affected by the polyphenols. Cycloheximide inhibited protein synthesis in the 3 cell types examined but paradoxically, in Caco-2 cells it caused increased specific activities of alkaline phosphatase and dipeptidyl peptidase. Several plant polyphenols can inhibit the growth of colon cancer cells but increased specific activity of some differentiation markers seen in Caco-2 cells did not appear to be a general phenomenon in colon cancer cells.
Michael A Lea; Chinwe Ibeh; Lydia Han; Charles Desbordes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  IM    
Department of Biochemistry and Molecular Biology, UMDNJ - New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA.
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MeSH Terms
Alkaline Phosphatase / metabolism
Antigens, Differentiation / metabolism*
Cell Differentiation / drug effects*
Cell Line, Tumor
Cell Proliferation / drug effects
Colonic Neoplasms / drug therapy*,  metabolism,  pathology
Flavonoids / pharmacology*
Histone Deacetylase Inhibitors / pharmacology*
Histone Deacetylases / chemistry*,  metabolism
Phenols / pharmacology*
Reg. No./Substance:
0/Antigens, Differentiation; 0/Flavonoids; 0/Histone Deacetylase Inhibitors; 0/Phenols; 0/polyphenols; EC Phosphatase; EC Deacetylases

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