Document Detail


Inhibition of glycolysis alters potassium ion transport and mitochondrial redox activity in rat brain.
MedLine Citation:
PMID:  2848047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine the relationships between brain glycolysis, ion transport, and mitochondrial reduction/oxidation (redox) activity, extracellular potassium ion activity (K+0) and redox shifts of cytochrome oxidase (cytochrome a,a3) were recorded previous to and during superfusion of rat cerebral cortex with the glycolytic inhibitor iodoacetic acid (IAA). IAA produced oxidation of cytochrome a,a3, increased local oxygenation, increased K+0, and, in response to neuronal activation, slowed rates of K+0 reaccumulation. Rates of rereduction of cytochrome a,a3, after the oxidation of this cytochrome by stimulation, were also slowed by IAA. These effects of IAA demonstrate the dependence of K+0 reaccumulation on the integrity of glycolysis, support the concept that active processes are involved in brain ion transport, and suggest a link between ATP supplied by glycolysis and ion transport activity. These data are also compatible with the suggestion that residual dysfunctions after brain ischemia result from derangements in glycolytic functioning rather than from limitations in oxygen availability or oxidative metabolic activity.
Authors:
C N Raffin; T J Sick; M Rosenthal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  8     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-06     Completed Date:  1989-01-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  857-65     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Miami School of Medicine, Florida 33101.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Brain / drug effects,  enzymology,  metabolism*
Electron Transport Complex IV / metabolism
Female
Glycolysis*
Iodoacetates / pharmacology
Iodoacetic Acid
Ions
Male
Mitochondria / enzymology,  metabolism*
Oxidation-Reduction* / drug effects
Potassium / metabolism*
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
HL38657/HL/NHLBI NIH HHS; NS05820/NS/NINDS NIH HHS; NS14325/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Iodoacetates; 0/Ions; 64-69-7/Iodoacetic Acid; 7440-09-7/Potassium; EC 1.9.3.1/Electron Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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