| Inhibition of glutamate dehydrogenase activity in rabbit renal mitochondria by phosphoenolpyruvate. | |
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MedLine Citation:
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PMID: 6628669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of phosphoenolpyruvate on glutamate dehydrogenase activity was studied in both intact and Triton X-100-treated rabbit renal mitochondria. The intramitochondrial phosphoenolpyruvate content was modulated by application of both 3-MPA, an inhibitor of phosphoenolpyruvate carboxykinase, and BTCA, which inhibits the tricarboxylate-transporting system. The data indicate that: (i) phosphoenolpyruvate is a potent inhibitor of glutamate dehydrogenase activity; and (ii) its inhibitory effect on the enzyme may be abolished by leucine and ADP, activators of glutamate dehydrogenase. |
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Authors:
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J Bryła; M Matyaszczyk |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 162 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 244-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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pharmacology Animals Benzene Derivatives / pharmacology Chemical Phenomena Chemistry Glutamate Dehydrogenase / antagonists & inhibitors* Kidney / enzymology* Leucine / pharmacology Male Mitochondria / enzymology Phosphoenolpyruvate / pharmacology* Picolinic Acids / pharmacology Rabbits Tricarboxylic Acids / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Benzene Derivatives; 0/Picolinic Acids; 0/Tricarboxylic Acids; 14623-54-2/3-mercaptopicolinic acid; 569-51-7/benzene 1,2,3-tricarboxylic acid; 58-64-0/Adenosine Diphosphate; 61-90-5/Leucine; 73-89-2/Phosphoenolpyruvate; EC 1.4.1.2/Glutamate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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