Document Detail

Inhibition of glucose oxidation by alpha-cyano-4-hydroxycinnamic acid stimulates feeding in rats.
MedLine Citation:
PMID:  14741234     Owner:  NLM     Status:  MEDLINE    
Alpha-cyano-4-hydroxycinnamic acid (4-CIN, 100-200 mg/kg b.wt.), which impairs glucose oxidation by inhibiting pyruvate transport across the mitochondrial membrane, stimulated feeding in rats following intraperitoneal injection without affecting blood glucose level. Like 2-deoxy-D-glucose (2-DG), an inhibitor of glycolysis, 4-CIN probably acts mainly on the CNS through activation of alpha(2)-adrenergic receptors, because the feeding response to 4-CIN was eliminated by phentolamine or yohimbine. Unlike feeding elicited by 2-DG, 4-CIN-induced feeding was eliminated by total abdominal (but not hepatic branch) vagotomy. Since peripheral atropinization also blocked 4-CIN-induced feeding, activation of central parasympathetic neurons seems to be involved in 4-CIN-induced feeding. The feeding response to 4-CIN was diminished in rats fed a high-fat diet, probably because metabolic sensors sensing fatty acid oxidation counteract the feeding response to 4-CIN. The results suggest that inhibition of glucose oxidation by blocking pyruvate entry into mitochondria stimulates feeding in rats in particular when fed a high-carbohydrate diet.
E Del Prete; T A Lutz; E Scharrer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  80     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-26     Completed Date:  2004-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  489-98     Citation Subset:  IM    
Institute of Veterinary Physiology, Winterthurerstr 260, CH-8057 Zürich, Switzerland.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Atropine / pharmacology
Blood Glucose / metabolism*
Coumaric Acids / pharmacology*
Deoxyglucose / metabolism
Dietary Carbohydrates / metabolism
Dietary Fats / metabolism
Drug Interactions
Eating / drug effects
Feeding Behavior / drug effects*
Monosaccharide Transport Proteins / antagonists & inhibitors*,  metabolism
Parasympatholytics / pharmacology
Phentolamine / pharmacology
Pyruvic Acid / antagonists & inhibitors*,  metabolism
Rats, Sprague-Dawley
Yohimbine / pharmacology
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Blood Glucose; 0/Coumaric Acids; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Monosaccharide Transport Proteins; 0/Parasympatholytics; 127-17-3/Pyruvic Acid; 146-48-5/Yohimbine; 154-17-6/Deoxyglucose; 28166-41-8/alpha-cyano-4-hydroxycinnamate; 50-60-2/Phentolamine; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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