Document Detail

Inhibition of gastric tumorigenesis by alpha-difluoromethylornithine in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine.
MedLine Citation:
PMID:  8335678     Owner:  NLM     Status:  MEDLINE    
Male Wistar rats were treated concurrently with a combination of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG; CAS 70-25-7) and the polyamine-synthesis inhibitor alpha-difluoromethylornithine (DFMO) at two different doses of 0.5% and 1.0% (w/v). Experimental groups were treated with (I) MNNG alone (n = 25), (II) MNNG plus 0.5% (w/v) DFMO (n = 25), (III) MNNG plus 1.0% (w/v) DFMO (n = 25), (IV) 1.0% (w/v) DFMO alone (n = 25). Group V represented untreated controls (n = 20). Both the carcinogen and DFMO were administered in drinking water. The treatment time with the carcinogen and DFMO was 35 weeks. After treatment was completed animals were followed for an additional 50 weeks to cover a total observation time of 85 weeks. Significantly fewer animals developed gastric adenocarcinoma in the two groups of animals that received a combined treatment of MNNG plus DFMO compared to animals treated with the carcinogen alone (P < 0.05 and 0.005). No benign or malignant neoplastic lesions were observed in the stomach or duodenum of animals treated with DFMO alone or in untreated controls. It is concluded that concurrent treatment with DFMO prevents the development of malignant gastric epithelial tumors induced by MNNG in rats.
T Lehnert; K Buhl; S Ivankovic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  119     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-26     Completed Date:  1993-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  594-8     Citation Subset:  IM    
Department of Surgery, University of Heidelberg, Germany.
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MeSH Terms
Adenocarcinoma / chemically induced,  prevention & control
Adenoma / chemically induced,  prevention & control
Cell Transformation, Neoplastic
Duodenal Neoplasms / chemically induced,  prevention & control
Eflornithine / administration & dosage,  therapeutic use*
Rats, Wistar
Sarcoma, Experimental / chemically induced,  prevention & control
Stomach Neoplasms / chemically induced,  prevention & control*
Reg. No./Substance:
70-25-7/Methylnitronitrosoguanidine; 70052-12-9/Eflornithine

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