Document Detail


Inhibition of gastric tumorigenesis by alpha-difluoromethylornithine in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine.
MedLine Citation:
PMID:  8335678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Male Wistar rats were treated concurrently with a combination of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG; CAS 70-25-7) and the polyamine-synthesis inhibitor alpha-difluoromethylornithine (DFMO) at two different doses of 0.5% and 1.0% (w/v). Experimental groups were treated with (I) MNNG alone (n = 25), (II) MNNG plus 0.5% (w/v) DFMO (n = 25), (III) MNNG plus 1.0% (w/v) DFMO (n = 25), (IV) 1.0% (w/v) DFMO alone (n = 25). Group V represented untreated controls (n = 20). Both the carcinogen and DFMO were administered in drinking water. The treatment time with the carcinogen and DFMO was 35 weeks. After treatment was completed animals were followed for an additional 50 weeks to cover a total observation time of 85 weeks. Significantly fewer animals developed gastric adenocarcinoma in the two groups of animals that received a combined treatment of MNNG plus DFMO compared to animals treated with the carcinogen alone (P < 0.05 and 0.005). No benign or malignant neoplastic lesions were observed in the stomach or duodenum of animals treated with DFMO alone or in untreated controls. It is concluded that concurrent treatment with DFMO prevents the development of malignant gastric epithelial tumors induced by MNNG in rats.
Authors:
T Lehnert; K Buhl; S Ivankovic
Related Documents :
2306708 - Carcinogenicity studies with deltamethrin in mice and rats.
3594718 - Nickel--magnesium interactions in carcinogenesis: dose effects and involvement of natur...
10817668 - Lack of oxidative dna damage or initiation of carcinogenesis in the kidneys of male f34...
608518 - Experimental evaluation of nonspecific immunostimulation and chemotherapy in the intrac...
7469788 - Dose-dependent neurochemical changes during short-term inhalation exposure to m-xylene.
24045778 - Expression of presynaptic markers in a neurodevelopmental animal model with relevance t...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  119     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-26     Completed Date:  1993-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  594-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Heidelberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / chemically induced,  prevention & control
Adenoma / chemically induced,  prevention & control
Animals
Cell Transformation, Neoplastic
Duodenal Neoplasms / chemically induced,  prevention & control
Eflornithine / administration & dosage,  therapeutic use*
Male
Methylnitronitrosoguanidine*
Rats
Rats, Wistar
Sarcoma, Experimental / chemically induced,  prevention & control
Stomach Neoplasms / chemically induced,  prevention & control*
Chemical
Reg. No./Substance:
70-25-7/Methylnitronitrosoguanidine; 70052-12-9/Eflornithine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The value of tumour spread, grading and growth pattern as morphological predictive parameters in bla...
Next Document:  Microregional distributions of glucose, lactate, ATP and tissue pH in experimental tumours upon loca...