Document Detail


Inhibition of gastric acid secretion elicited by D-glucose anomers in man.
MedLine Citation:
PMID:  6368258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acid outputs from the stomach were measured after venous administration of D-glucose and its optical anomers in men with insulin hypoglycemia. A significant decrease in gastric acid output was noted after the administration of 277 mM alpha-D-glucose, 277 mM optically equilibrated D-glucose consisting of 36% alpha-anomer and 64% beta-anomer, or 277 mM beta-D-glucose. The effect of beta-D-glucose was most potent in the three forms of D-glucose. NaCl solution, however, produced no appreciable change in the acid outputs. Our findings suggested that, in humans, beta-D-glucose in the blood may play an important role in the activation of glucose-sensitive mechanisms controlling vagally mediated secretion of gastric acid.
Authors:
T Sakaguchi; K Ishiguro; Y Hayashi; A Hasegawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental neurology     Volume:  84     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Gastric Acid / secretion*
Gastric Juice / drug effects*
Glucose / pharmacology*
Humans
Hypoglycemia / metabolism
Insulin
Male
Stereoisomerism
Chemical
Reg. No./Substance:
11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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