| Inhibition of gastric acid secretion elicited by D-glucose anomers in man. | |
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MedLine Citation:
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PMID: 6368258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acid outputs from the stomach were measured after venous administration of D-glucose and its optical anomers in men with insulin hypoglycemia. A significant decrease in gastric acid output was noted after the administration of 277 mM alpha-D-glucose, 277 mM optically equilibrated D-glucose consisting of 36% alpha-anomer and 64% beta-anomer, or 277 mM beta-D-glucose. The effect of beta-D-glucose was most potent in the three forms of D-glucose. NaCl solution, however, produced no appreciable change in the acid outputs. Our findings suggested that, in humans, beta-D-glucose in the blood may play an important role in the activation of glucose-sensitive mechanisms controlling vagally mediated secretion of gastric acid. |
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Authors:
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T Sakaguchi; K Ishiguro; Y Hayashi; A Hasegawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental neurology Volume: 84 ISSN: 0014-4886 ISO Abbreviation: Exp. Neurol. Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-05-11 Completed Date: 1984-05-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 231-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Gastric Acid / secretion* Gastric Juice / drug effects* Glucose / pharmacology* Humans Hypoglycemia / metabolism Insulin Male Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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