Document Detail


Inhibition of gastric H+, K+-ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale.
MedLine Citation:
PMID:  17295419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ulcer is a common global problem characterized by acute gastric irritability, bleeding, etc. due to either increased gastric cell proton potassium ATPase activity (PPA) or perturbation of mucosal defence. Helicobacter pylori has been identified as a major ulcerogen in addition to oxidative stress and nonsteroidal anti-inflammatory drugs. In this paper, we report ginger-free phenolic (GRFP) and ginger hydrolysed phenolic (GRHP) fractions of ginger (Zingiber officinale) as potent inhibitors of PPA and H. pylori growth. GRFP and GRHP inhibited PPA at an IC(50) of 2.9 +/- 0.18 and 1.5 +/- 0.12 microg/mL, exhibiting six- to eight-fold better potency over lansoprazole. GRFP is constituted by syringic (38%), gallic (18%) and cinnamic (14%) acids and GRHP by cinnamic (48%), p-coumaric (34%) and caffeic (6%) acids as major phenolic acids. GRFP and GRHP further exhibited free radical scavenging (IC(50) 1.7 +/- 0.07 and 2.5 +/- 0.16), inhibition of lipid peroxidation (IC(50) 3.6 +/- 0.21 and 5.2 +/- 0.46), DNA protection (80% at 4 microg) and reducing power abilities (80-338 U/g) indicating strong antioxidative properties. GRFP and GRHP may thus be potential in-expensive multistep blockers against ulcer.
Authors:
Mugur N Siddaraju; Shylaja M Dharmesh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  51     ISSN:  1613-4125     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-12     Completed Date:  2007-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  324-32     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore 570-020, Karnataka, India.
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MeSH Terms
Descriptor/Qualifier:
2-Pyridinylmethylsulfinylbenzimidazoles / pharmacology
Antioxidants / pharmacology
Caffeic Acids / pharmacology
Cinnamates / pharmacology
Coumaric Acids / pharmacology
Enzyme Inhibitors / pharmacology
Gallic Acid / analogs & derivatives,  pharmacology
Gastric Mucosa / enzymology*
Ginger / chemistry*
H(+)-K(+)-Exchanging ATPase / antagonists & inhibitors*
Helicobacter pylori / drug effects*,  growth & development*
Lipid Peroxidation / drug effects
Phenols / pharmacology*
Chemical
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Antioxidants; 0/Caffeic Acids; 0/Cinnamates; 0/Coumaric Acids; 0/Enzyme Inhibitors; 0/Phenols; 103577-45-3/lansoprazole; 149-91-7/Gallic Acid; 331-39-5/caffeic acid; 530-57-4/syringic acid; 621-82-9/cinnamic acid; 7400-08-0/4-coumaric acid; EC 3.6.1.10/H(+)-K(+)-Exchanging ATPase

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