Document Detail


Inhibition of exercise-induced asthma by nifedipine: a dose-response study.
MedLine Citation:
PMID:  3689629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The effect of three single doses of nifedipine on exercise-induced asthma has been examined in 11 asthmatic subjects. 2. On four separate days patients undertook 6 min of exercise on a treadmill 30 min after taking placebo or nifedipine 10, 20 or 30 mg administered double-blind and in random order. 3. Nifedipine had no significant effect on resting FEV1 measurements. 4. Nifedipine, in doses of 10, 20 and 30 mg, inhibited exercise induced bronchoconstriction, reducing the maximum fall in FEV1 from 30.8 +/- 3.5% after placebo to 21.9 +/- 3.4% (NS), 13 +/- 3.4% (P less than 0.01) and 15 +/- 3.9% (P less than 0.01) respectively. 5. This study has shown that the protective effect of nifedipine against exercise-induced asthma is dose related with the maximum inhibitory effect being observed with a single dose of 20 mg.
Authors:
P Rafferty; J G Varley; J S Edwards; S T Holgate
Related Documents :
10227269 - Cough as the ambiguous indicator of airway obstruction in asthma.
6359989 - Effects of inhaled budesonide alone and in combination with low-dose terbutaline in chi...
1750339 - Psychological and respiratory physiological effects of a physical exercise programme on...
21076349 - Management of exercise-induced bronchospasm in adolescents with asthma.
23591949 - Improvements in hip flexibility do not transfer to mobility in functional movement patt...
7582279 - Cytokines in bronchoalveolar lavage fluid of patients with nocturnal asthma.
16640949 - Management of lower extremity malalignment during running with neuromuscular retraining...
6721269 - Asthma induced by suggestion: is it due to airway cooling?
23575109 - Direct observation is a valid criterion for estimating physical activity and sedentary ...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  24     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-02-10     Completed Date:  1988-02-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Affiliation:
Medicine 1, Centre Block, Southampton General Hospital, Hampshire.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / drug therapy*
Asthma, Exercise-Induced / drug therapy*,  physiopathology
Dose-Response Relationship, Drug
Female
Forced Expiratory Volume
Humans
Male
Nifedipine / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
21829-25-4/Nifedipine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The trans-hepatic extraction of nifedipine.
Next Document:  Inhibition of artificially induced cough in man by bronchodilators.