Document Detail


Inhibition of exercise-induced asthma by nifedipine: a dose-response study.
MedLine Citation:
PMID:  3689629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The effect of three single doses of nifedipine on exercise-induced asthma has been examined in 11 asthmatic subjects. 2. On four separate days patients undertook 6 min of exercise on a treadmill 30 min after taking placebo or nifedipine 10, 20 or 30 mg administered double-blind and in random order. 3. Nifedipine had no significant effect on resting FEV1 measurements. 4. Nifedipine, in doses of 10, 20 and 30 mg, inhibited exercise induced bronchoconstriction, reducing the maximum fall in FEV1 from 30.8 +/- 3.5% after placebo to 21.9 +/- 3.4% (NS), 13 +/- 3.4% (P less than 0.01) and 15 +/- 3.9% (P less than 0.01) respectively. 5. This study has shown that the protective effect of nifedipine against exercise-induced asthma is dose related with the maximum inhibitory effect being observed with a single dose of 20 mg.
Authors:
P Rafferty; J G Varley; J S Edwards; S T Holgate
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  24     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-02-10     Completed Date:  1988-02-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Affiliation:
Medicine 1, Centre Block, Southampton General Hospital, Hampshire.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / drug therapy*
Asthma, Exercise-Induced / drug therapy*,  physiopathology
Dose-Response Relationship, Drug
Female
Forced Expiratory Volume
Humans
Male
Nifedipine / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
21829-25-4/Nifedipine
Comments/Corrections

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