Document Detail

Inhibition of exercise-induced asthma by nifedipine: a dose-response study.
MedLine Citation:
PMID:  3689629     Owner:  NLM     Status:  MEDLINE    
1. The effect of three single doses of nifedipine on exercise-induced asthma has been examined in 11 asthmatic subjects. 2. On four separate days patients undertook 6 min of exercise on a treadmill 30 min after taking placebo or nifedipine 10, 20 or 30 mg administered double-blind and in random order. 3. Nifedipine had no significant effect on resting FEV1 measurements. 4. Nifedipine, in doses of 10, 20 and 30 mg, inhibited exercise induced bronchoconstriction, reducing the maximum fall in FEV1 from 30.8 +/- 3.5% after placebo to 21.9 +/- 3.4% (NS), 13 +/- 3.4% (P less than 0.01) and 15 +/- 3.9% (P less than 0.01) respectively. 5. This study has shown that the protective effect of nifedipine against exercise-induced asthma is dose related with the maximum inhibitory effect being observed with a single dose of 20 mg.
P Rafferty; J G Varley; J S Edwards; S T Holgate
Related Documents :
1617389 - Precipitating factors of asthma.
23893149 - Acute effects of hamstring-stretching exercises on the kinematics of the lumbar spine a...
9256519 - Thought suppression in spider phobia.
25131059 - Effect of platelet-rich plasma therapy associated with exercise training in musculoskel...
24048909 - The benefits of a high-intensity aquatic exercise program (hydros) for bone metabolism ...
8430919 - Preventive effect and duration of action of disodium cromoglycate and procaterol on exe...
25051209 - Functional performance of female patients more than 6 months after total hip arthroplas...
11718279 - Blood pressure and heart rate response to isometric exercise: the effect of spinal cord...
22665409 - Hyponatremia-associated rhabdomyolysis following exercise in an adolescent with cystic ...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  24     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-02-10     Completed Date:  1988-02-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Medicine 1, Centre Block, Southampton General Hospital, Hampshire.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Asthma / drug therapy*
Asthma, Exercise-Induced / drug therapy*,  physiopathology
Dose-Response Relationship, Drug
Forced Expiratory Volume
Nifedipine / adverse effects,  therapeutic use*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The trans-hepatic extraction of nifedipine.
Next Document:  Inhibition of artificially induced cough in man by bronchodilators.